Riding low coming into Wednesday's game at Camden Yards off 19 straight losses, home fans didn't come to Oriole Park to possibly watch a 20th straight. They came to see the best two-way player in baseball, Shohei Ohtani, pitch for the Angels. 

That is, until Baltimore's leadoff centerfielder Cedric Mullins sent Ohtani's first pitch 415 yards for his 22nd home run of the season, of course. 

Two batters later, right fielder Anthony Santander hit his 13th home run of the season. 

The stellar slugging from the O's comes after their 14-8 series-opening loss to Ohtani's Angels on Tuesday when Baltimore was down 13-2 after the first four innings. The exact opposite was the case Wednesday night as Baltimore started well out of the gates with those two home runs. 

Since July, Ohtani has led MLB in ERA (1.58), WHIP (0.75), and opponent OPS (.505) and is 5-0. The best pitcher and hitter on his own team ran into a hungry Orioles squad determined to end quite a trying streak of losses. 

The Orioles became the first team to hit two home runs in the same game against Ohtani, doing so with two of their first four at-bats according to MASN's Steve Meleweski.