Jackson was a full participant at Ravens practice on Friday after missing the prior two days due to the illness. He tested it out at Soldier Field prior to kickoff, but was ultimately deemed unable to play.
The 2019 MVP has only missed two games in his career since being named Baltimore's starting quarterback in the middle of his rookie season. The Ravens chose to sit Jackson along with several other starters for their Week 17 game against the Steelers in 2019, and Jackson was on the COVID-19 list during Baltimore's Week 12 loss to Pittsburgh in 2020.
Second-year quarterback Tyler Huntley will make his first career start in place of Jackson. The former Utah Ute has only thrown 16 regular-season passes in his career and last played during the Ravens' Week 7 loss to the Bengals.