With the running game expected to take center stage in a rain-soaked M&T Bank Stadium on Sunday, it appears the 49ers (10-1) will be without an important weapon once again.
Running back Matt Breida, who has missed the last two games with an ankle injury, will not play against the Ravens, ESPN's Adam Schefter reported, citing a source.
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Schefter had previously reported that Breida would return for Sunday's showdown.
With rain expected throughout the day in Baltimore, the 49ers and Ravens (9-2) might have to lean heavily on their running backs.
While Tevin Coleman leads the 49ers with six rushing touchdowns, Breida leads the team with 542 rushing yards this season.
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San Francisco 49ers
With the Seahawks (9-2) and Saints (10-2) breathing down the 49ers' necks in the NFC playoff picture, they need to go into Baltimore and emerge with a victory.
Without Breida, it's a tougher task.