Mixon failed to stick with an NFL franchise during the 2025 season after starting 14 games for the Texans in 2024. The 30-year-old back has over 1,800 carries at the professional level to his name and brings a veteran presence to a Seattle backfield reeling the wake of rookie Jadarian Price’s placement on injured reserve. Zach Charbonnet saw his 21-day practice window activated as he attempts to return from injured reserve, although it could take him another week or two to be activated considering the timing of his knee injury a season ago. Emanuel Wilson could see another week of lead-back usage alongside George Holani as Mixon gets up to speed with the offense.

It’s been an odd 24 hours for Love, who was quoted after Sunday’s game saying this is shaping up to be the “longest year” of his career while also adding that he’s “tired” and would be willing to pass off work to Tyler Allgeier or Bam Knight in the event that he doesn’t think he can do what is being asked of him. As for this latest injury, LaFleur said the ankle injury isn’t the same one Love injured in the preseason, meaning he now has two ankle injuries to manage for the rest of the season. The Cardinals’ backfield was already proving hard to predict, and the latest quote from Love, coupled with the injury news, doesn’t exactly instill more confidence in him going forward. He draws a plus Week 5 matchup against the Lions, but should be treated as a fringe RB2/RB3 for now.

Rapoport reports there are hopes that Bigsby will be back “in six weeks or shorter.” The 24-year-old back will be required to miss at least four games now that he’s headed for an IR stint. With Saquon Barkley (hamstring) also at risk of missing at least one game, third-string RB Will Shipley could be in line for a busy day in Week 5 against the Jaguars. Shipley rushed six times for 23 yards in Sunday’s loss to the Rams, but could be a sneaky option in PPR leagues given his pass-catching profile during his days at Clemson, when he caught 85 passes over three seasons. It also wouldn’t be surprising if Dameon Pierce or Jaydon Blue were promoted off the practice squad and saw early down touches while Shipley serves in more of a third-down role. There’s a lot to figure out here over the next few days.

Barkley went down early in Sunday’s loss to the Rams and did not return to the game. NFL Network’s Ian Rapoport said earlier on Monday that Barkley’s injury “does not seem to be overly serious,” but with the Eagles taking on the Jaguars in London next week, it wouldn’t be surprising if he missed at least one game. Backup Tank Bigsby led the Eagles with 55 rushing yards on 14 carries and could be a viable RB2 if Barkley is out.

Chase exited Week 4’s game against the Jaguars with a brain injury and didn’t return to the game. He will now need to clear a series of tests in the coming days if he hopes to be cleared in time to play in the Bengals’ Week 5 game against the Dolphins. Chase caught three passes for 27 yards before leaving Sunday’s game against the Jaguars and has caught 21 passes for 212 yards and three touchdowns this season. If he’s unable to play, Dohnte Meyers, who has seen 14 targets over the last two weeks, could be worth a stash in deeper leagues with Tee Higgins (adductor) also considered day-to-day to start the week.

Taylor said that the team would see where he is at this week. It sounds like the practice reports will loom large for Higgins ahead of next Sunday’s game. Dohnte Meyers took on a big role in the absence of Ja’Marr Chase (concussion) Sunday and could have even more of a runway if both Higgins and Chase are sidelined this week.

We assumed this was where things were heading after Bagent turned in a solid outing in his first start against the Jets. Bagent has been the QB2 on the Bears’ depth chart throughout the season and only missed Week 3’s start against the Eagles because he spent most of the week in the league’s concussion protocol. Bagent threw for 268 yards and one interception in Sunday’s win over the Jets and will have some appeal in 2QB/Superflex leagues, especially with the Chiefs and Panthers both on byes in Week 5.

ESPN’s Adam Schefter reports that Rosenhaus will begin negotiating a deal for Hill with multiple teams. Among these teams is the Chiefs, who lost both Rashee Rice (hamstring) and Tyquan Thornton (ankle) in Week 4’s win over the Raiders. It was reported on Sunday night that the Chiefs have been in contact with Hill about a potential return. Now, it’s safe to say the Chiefs have a real need at the position that Hill could fill should the two reunite. It’s hard to know how soon Hill can contribute on the field, as he’s still working his way back from a brutal knee injury he suffered last season, but he’s posted videos of himself working out to his social media accounts to show he’s close to being ready to go. While other teams could emerge as suitors for Hill, the Chiefs feel like the most obvious landing spot right now.

The Saints’ offense has managed just fine without Tyson, but it doesn’t sound like it will get a boost from the rookie first-rounder any time soon. According to Schefter, Tyson is “making progress and feeling good,” but the earliest we may see him is Week 7. That said, due to the Saints playing Week 7 in Paris, Schefter also notes that “the most logical” return date for Tyson could be Week 9 after the team’s bye week. Fantasy managers stashing Tyson will need to continue doing so for the next several weeks, and even when he’s active, it could take a few games for him to see a full assortment of snaps. We can expect Devaughn Vele to continue operating as the Saints’ WR2 behind Chris Olave until Tyson returns.

It was reported after Sunday’s win over the Titans that Jackson was “believed to be day-to-day” after he left the game with what appeared to be a relatively minor ankle injury. Jackson was spotted in a walking boot, which has raised a bit more concern for his Week 5 availability, but hopefully the MRI doesn’t reveal anything too severe. Jackson and the Ravens are set to take on the Falcons on Sunday night, which could make for a difficult situation for fantasy managers. We’ll surely receive countless updates on his status throughout the week, but fantasy managers should have a backup plan in place in the event he enters the weekend with a questionable designation. If he’s unable to play, Tyler Huntley would draw his first start of the season.