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Guardians at Royals Prediction: Odds, expert picks, starting pitchers, betting trends, and stats for July 25

It’s Friday, July 25 and the Guardians (51-51) are in Kansas City to take on the Royals (50-53). Gavin Williams is slated to take the mound for Cleveland against Michael Wacha for Kansas City.

Despite two homers from Steven Kwan on Thursday, the Guardians lost to the Orioles 4-3, but won the series 3-1. Cleveland is 5-2 in the seven games since the All-Star break and will go to Kansas City for a three-game series.

The Royals are 3-3 in six games after the break and coming off a series win over the Cubs (took 2 of 3). The Guardians are 4-2 against the Royals this season.

Let’s dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.

Game details & how to watch Guardians at Royals

  • Date: Friday, July 25, 2025
  • Time: 8:10PM EST
  • Site: Kauffman Stadium
  • City: Kansas City, MO
  • Network/Streaming: WKYC 3, Apple TV+

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Guardians at the Royals

The latest odds as of Friday:

  • Moneyline: Guardians (-101), Royals (-118)
  • Spread: Royals 1.5
  • Total: 8.0 runs

Probable starting pitchers for Guardians at Royals

  • Pitching matchup for July 25, 2025: Gavin Williams vs. Michael Wacha
    • Guardians: Gavin Williams, (6-4, 3.54 ERA)
      Last outing: 1.29 ERA, 1 Earned Runs Allowed, 4 Hits Allowed, 1 Walks, and 11 Strikeouts
    • Royals: Michael Wacha, (4-9, 3.62 ERA)
      Last outing: 1.50 ERA, 1 Earned Runs Allowed, 3 Hits Allowed, 1 Walks, and 1 Strikeouts

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Expert picks & predictions for tonight’s game between the Guardians and the Royals

Rotoworld Best Bet

Vaughn Dalzell (@VmoneySports) likes the Guardians to reach 80 wins:

“In the first 24 games of the 67 one second-half of the schedule are the Athletics, Orioles, Royals, Rockies, Twins, Mets, White Sox, and Marlins -- beautiful!

Cleveland took the series against the A’s, 2-1 and beat the O’s in three of four — so far so good at 5-2 in seven games.

The Guardians have the easiest strength of schedule remaining in the MLB and need a 34-33 record over the second half to secure 80-plus wins, which I believe is more than possible.”

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Friday’s game between the Guardians and the Royals:

  • Moneyline: NBC Sports Bet is recommending a play on the Cleveland Guardians on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the Cleveland Guardians at +1.5.
  • Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.

Top betting trends & insights to know ahead of Guardians at Royals

  • Cleveland is 5-2 in the last seven games
  • Kansas City is 3-3 in the last six games
  • The Guardians have won 4 of their last 5 road series
  • 5 of the Royals’ last 7 home games stayed under the Total
  • The Guardians have covered the Run Line in 3 straight road games against the Royals

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Follow our experts on socials to keep up with all the latest content from the staff:

  • Jay Croucher (@croucherJD)
  • Drew Dinsick (@whale_capper)
  • Vaughn Dalzell (@VmoneySports)
  • Trysta Krick (@Trysta_Krick)