Stung Southampton sits just one point above the relegation zone, and visits an angry Manchester United at Old Trafford on Saturday (Watch live at 12:30 p.m. ET on NBC and online via NBCSports.com).
United will have Anthony Martial and Marcus Rashford on the bench, while Southampton will keep Manolo Gabbiadini, Nathan Redmond, Steven Davis, and Mario Lemina in reserve.
Fraser Forster loses his place between the sticks in favor of Alex McCarthy.
Manchester United: De Gea, Young, Lindelof, Jones, Shaw, Matic, Pogba, Mata, Lingard, Mkhitaryan, Lukaku. Subs: Romero, Blind, Rojo, Tuanzebe, Herrera, Martial, Rashford.
Southampton: McCarthy, Stephens, Yoshida, Hoedt, McQueen, Romeu, Hojbjerg, Tadic, Ward-Prowse, Boufal, Long. Subs: Forster, Pied, Bednarek, Davis, Lemina, Redmond, Gabbiadini.