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Jaguars vs. Bills prediction: Odds, best bets, player news, injury updates, trends, and stats for Week 3

Can the Jacksonville Jaguars avoid going 0-3 to start the season by defeating the Buffalo Bills on the road?

Since 1979, only six teams have made the playoffs after starting 0-3. Only one team has ever started 0-3 and won a playoff game, that team failed to make the Super Bowl that season.

It’s an uphill battle for the Jags, and they are playing against a strong Buffalo Bills team who look poised to win the AFC East and hunt for a Super Bowl berth.

NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.

Listen to the Bet the Edge podcast as hosts Jay Croucher and Drew Dinsick provide listeners with sharp actionable insight, market analysis and statistical data to help bettors gain more information before placing their wagers. So, whether you’re targeting spreads and totals, looking for value in futures markets or circling player props, give their podcast a listen to give you that extra edge.

How to watch Jacksonville Jaguars vs. Buffalo Bills live Monday night

  • Date: Monday, September 23, 2024
  • Time: 7:30 PM EST
  • Site: Highmark Stadiunm
  • City: Orchard Park, NY
  • TV/Streaming: ESPN

Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!

Latest Game odds for Jacksonville Jaguars vs. Buffalo Bills - Week 3

The latest odds as of Friday courtesy of DraftKings:

  • Moneyline: Jacksonville Jaguars (+190), Buffalo Bills (-230)
  • Spread: Bills -5
  • Total: 45.5

The line opened up at -6.0 in favor of the Bills and has dropped to -5 at DraftKings. The Total has dropped an entire point from 46.5.

Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!

NBC Sports Bet Best Bets

Brad Thomas (@MrBradThomas) thinks the play here is the under…
“Monday night games have tended to go under. With both teams relying heavily on the run and both defenses playing solid, 45.5 may be too many points for over bettors to cash their tickets.”

Jacksonville Jaguars vs. Buffalo Bills team stats, betting trends

  • Jacksonville is 2-6 against the spread in their last eight games
  • Buffalo is 2-0 against the spread to start the season
  • The Jaguars are 0-6 S/U in their last six games against the AFC
  • Josh Allen is 3-5 on Monday Night Football

Quarterback matchup for Jacksonville Jaguars vs. Buffalo Bills

  • Jaguars – Trevor Lawrence signed a 5-year, $275,000,000 contract in the offseason. He is set to $55 million per year.
  • Bills – Josh Allen has started the season in decent shape. He has led the Bills to a 2-0 record with 371 passing yards and 3 TDs

Player news & injuries

  • Jacksonville RB Tank Bigsby (shoulder) is questionable
  • Buffalo LB Matt Milano (bicep) is OUT
  • Jacksonville S Darnell Savage is questionable
  • Buffalo CB Taron Johnson (forearm) is questionable

Rotoworld still has you covered with all the latest betting info & tools for NFL with game predictions, player props, futures, and trends!

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