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Cubs vs Tigers Prediction: Odds, recent stats, trends, and best bets for July 22

Chicago (57-44) dominated Detroit (47-54) on Tuesday, 11-2, setting up a series finale on ESPN. Both teams are 3-2 in their last five games and won the first series of the second half.

The Cubs sit firmly in the drivers seat of the NL Wild Card, while the Tigers are five games back in the AL Wild Card race. Chicago is hitting .290 out of the break (7th) and has a 2.93 ERA (6th). The Cubs are tied for the fourth-most runs scored (35) since the All-Star break whereas the Tigers are tied for 17th (21).

Detroit has scored two or fewer runs in three of their first five games since the All-Star break and are hitting .227 as a group (22nd). The Tigers went on a sweet stretch of nine wins and three losses entering the All-Star break, so despite the semi-cold hitting, Detroit is warming up in the wins department.

Let’s dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.

Game details & how to watch Tigers at Cubs

  • Date: Wednesday, July 22, 2026
  • Time: 8:00 PM EST
  • Site: Wrigley Field
  • City: Chicago, IL
  • Network/Streaming: ESPN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Tigers at the Cubs

The latest odds as of Wednesday:

  • Moneyline: Chicago Cubs (-125), Detroit Tigeras (+104)
  • Spread: Tigers +1.5 (-208), Cubs -1.5 (+170)
  • Total: 8.0

Probable starting pitchers for Tigers at Cubs

  • Wednesday’s pitching matchup (July 22): Keider Montero vs. Colin Rea
  • Tigers: Keider Montero

2026 stats: 100.2 IP, 6-5, 3.22 ERA, 1.42 WHIP, 76 K, 37 BB

  • Cubs: Colin Rea

2026 Stats: 100.2 IP, 7-6, 4.74 ERA, 1.77 WHIP, 73 K, 38 BB

Who’s Hot? Who’s Not

  • The Cubs’ Pete Crow-Armstrong is hitting .285 with 107 hits, 21 home runs and 55 RBI over 376 at-bats
  • The Cubs’ Dansby Swanson is hitting .215 with 71 hits and 86 strikeouts over 331 at-bats
  • The Tigers’ Kevin McGonigle is hitting .282 with 104 hits, 9 home runs, and 35 RBI over 369 at-bats
  • The Tigers’ Spencer Torkelson is hitting .205 with 70 hits and 127 strikeouts over 342 at-bats

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Tigers at Cubs

  • Detroit is 52-49 ATS
  • Chicago is 45-56 ATS, ranking sixth-worst
  • Detroit is 54-43-4 to the Under, ranking fourth-best
  • Chicago is 54-46-1 to the Over, ranking ninth-best
  • Detroit is 22-28 ATS on the road, ranking fourth-worst
  • Chicago is 20-31 ATS at home, ranking third-worst

Expert picks & predictions for tonight’s game between the Cubs and the Tigers

Rotoworld Bet Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Wednesday’s game between the Tigers and the Cubs:

  • Moneyline: NBC Sports Bet is recommending a play on the Cubs on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the Cubs at -1.5.
  • Total: NBC Sports Bet is recommending a play on the Over on the Game Total of 8.5

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  • Vaughn Dalzell (@VmoneySports)
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