The Padres (43-39) are coming off a 4-2 loss to the Dodgers (54-30) and now travel across the country for a road trip that starts in Chicago. The Cubs (46-38) are heating up over the past week, but they have struggled at home altogether on the month going 5-6 over 11 games.
Chicago is 6-1 in the last seven games and coming off a 4-3 win over Milwaukee in extra innings Sunday. Chicago has now tied or won five straight series but are still 6.5 games back of Milwaukee for first place in the NL. After losing four straight starts by Shota Imanaga, the Cubs have won three of the last four with three of those games being decided by one run.
San Diego has yet to announce a pitcher for this game and will likely roll with a starter and use relief pitchers a majority of the way. The Padres have had 11 road games this month and have come away with four wins. San Diego is hitting .226 on the road this season (28th) with bottom 10 ranks in OBP, SLG, and OPS. Over the last seven days, Manny Machado has two walk off winners and is hitting .300, which is a pleasant sign for San Diego fans.
Let’s dive into the matchup and find a sweat or two.
We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Padres at Cubs
- Date: Monday, June 29, 2026
- Time: 8:05 PM EST
- Site: Wrigley Field
- City: Chicago, IL
- Network/Streaming: MLB TV
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Odds for the Padres at the Cubs
The latest odds as of Monday:
- Moneyline: Chicago Cubs (-149), San Diego Padres (+123)
- Spread: Padres +1.5 (-149), Cubs -1.5 (+124)
- Total: 11.5
Probable starting pitchers for Padres at Cubs
- Monday’s pitching matchup (June 29): Shota Imanaga vs. Griffin Canning
- Cubs: Shota Imanaga
2026 stats: 92.0 IP, 5-6, 4.40 ERA, 1.05 WHIP, 88 Ks, 23 BB
- Padres: Griffin Canning
2026 Stats: 42.2 IP, 1-5, 7.38 ERA, 1.66 WHIP, 43 K, 26 BB
Who’s Hot? Who’s Not
- The Cubs’ Pete Crow-Armstrong is hitting .278 with 88 hits, 17 home runs and 45 RBI over 317 at-bats
- The Cubs’ Ian Happ is hitting .224 with 67 hits and 112 strikeouts over 299 at-bats
- The Padres’ Fernando Tatis Jr. is hitting .283 with 89 hits, 3 home runs, and 30 RBI over 314 at-bats
- The Padres’ Jackson Merrill is hitting .212 with 65 hits and 84 strikeouts over 306 at-bats
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Top betting trends & insights to know ahead of Padres at Cubs
- The Cubs are 34-50 ATS, ranking third-worst
- The Padres are 45-37 ATS, ranking seventh-best
- The Cubs are 45-38-1 to the Over, ranking eighth-best
- The Padres are 45-36-1 to the Under, ranking second-best
- The Cubs are an MLB-worst 14-26 ATS as the home team
- The Padres are 20-16 ATS as the road team, ranking eighth-best
Expert picks & predictions for tonight’s game between the Cubs and the Padres
Rotoworld Bet Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Monday’s game between the Padres and the Cubs:
- Moneyline: NBC Sports Bet is recommending a play on the Cubs on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the Cubs at -1.5.
- Total: NBC Sports Bet is recommending a play on the Over on the Game Total of 11.5
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