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Royals at Cardinals Game 2 prediction: Odds, expert picks, starting pitchers, trends, and stats for June 5

Its Thursday, June 5 and the Royals (32-29) are in St. Louis to take on the Cardinals (33-27) for a doubleheader following last night’s rainout.

Cole Ragans is slated to take the mound for Kansas City against Matthew Liberatore for St. Louis in Game 2.

The series opened Tuesday with a 10-7 Royals’ win. Bobby Witt Jr. drove in four to pace the offense which overcame an awful start from Michael Lorenzen who allowed seven runs in just 2.2 innings.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.

Game details & how to watch Royals at Cardinals - Game 2

  • Date: Thursday, June 5, 2025
  • Time: 7:45PM EST
  • Site: Busch Stadium
  • City: St. Louis, MO
  • Network/Streaming: FDSNKC, FDSNMW

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Royals at the Cardinals - Game 2

The latest odds as of Thursday:

  • Moneyline: Royals (-102), Cardinals (-117)
  • Spread: Cardinals 1.5
  • Total: 7.0 runs

Probable starting pitchers for Royals at Cardinals - Game 2

  • Pitching matchup for June 5, 2025: Cole Ragans vs. Matthew Liberatore
    • Royals: Cole Ragans (2-3, 4.53 ERA)
      Last outing: 5/16 vs. St. Louis - 5IP, 4ER, 5H, 0BB, 7Ks
    • Cardinals: Matthew Liberatore (3-4, 3.08 ERA)
      Last outing: 5/30 at Texas - 5IP, 4ER, 7H, 1BB, 5Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Royals at Cardinals - Game 2

  • The Cardinals are showing a 129% return on investment at home on the Money Line
  • Each of the Royals’ last 3 games in St. Louis have gone over the Total
  • The Royals have covered the Run Line in 10 of their last 12 road games against the Cardinals
  • Bobby Witt Jr. is 3-8 to open June after closing May with just 2 hits in his final 18 ABs

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Royals and the Cardinals

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Thursday’s Game 2 between the Royals and the Cardinals:

  • Moneyline: NBC Sports Bet is recommending a play on the St. Louis Cardinals on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the Kansas City Royals at +1.5.
  • Total: NBC Sports Bet is recommending a play on the over on the Game Total of 7.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

  • Jay Croucher (@croucherJD)
  • Drew Dinsick (@whale_capper)
  • Vaughn Dalzell (@VmoneySports)
  • Brad Thomas (@MrBradThomas)