49ers wide receiver Deebo Samuel was limited in his return to practice on Wednesday.
Samuel missed the past three games with a hamstring injury.
He had not practiced since Oct. 9.
Samuel has 16 catches for 206 yards and three touchdowns in five games.
The 49ers practiced without wide receiver Mike Evans (Achilles), cornerback Renardo Green (back), linebacker Dre Greenlaw (rest), cornerback Deommodore Lenoir (foot), running back Christian McCaffrey (rest) and left tackle Trent Williams (rest).
Safety Siran Neal (knee/foot), cornerback Upton Stout (shoulder/neck) and defensive tackle C.J. West (knee) were limited.