The Colts punted after their first drive but finally got it going on their second chance of the day.
Indianapolis went 92 yards on seven plays, with Parris Campbell catching a 51-yard touchdown pass from Carson Wentz with 1:52 remaining in the first quarter.
Wentz is 6-of-8 for 109 yards. Six different receivers have caught a pass.
The Texans have moved the ball with 78 yards in 18 plays after the first quarter.
Davis Mills is 8-of-10 for 51 yards.