The Titans got down to the 75-man roster limit by placing return man Marc Mariani on injured reserve, among other moves, according to Jim Wyatt of the Tennesseean.
Mariani suffered a Theismann-level broken leg Thursday night, fracturing the tibia and fibula in his left leg.
He had made the Pro Bowl as a return man in 2010, but was working to become more a part of the offense.
The Titans also placed safety Markelle Martin on PUP, and released the following players: Running back Herb Donaldson, center William Vlachos, quarterback Nick Stephens, kicker Will Batson, tight end Joey Haynos, offensive linemen George Bias and Jonathan Palmer, safety Christian Scott and wide receivers Chase Deadder, LaQuinton Evans and Marcus Harris.