Jeff Wilson rushed for 110 yards and a touchdown last week. He already has a touchdown Thursday night.
Wilson ran for a 1-yard score after the 49ers took the opening kickoff and went 75 yards in nine plays.
Jimmy Garoppolo went 5-for-5 for 59 yards.
Deebo Samuel was the star. He rushed for 8 yards on one carry and caught two passes for 33 yards. His 23-yard reception got the 49ers to the 1-yard line, setting up Wilson’s score on the next play.
Brandon Aiyuk caught two passes for 21 yards.
The 49ers did not face a third down in the opening drive.