For the second time in three weeks, the San Francisco 49ers and the Seattle Seahawks face off. While the division title and top seed in the NFC were on the line three weeks ago, the stakes are even higher this weekend. The winner advances to the NFC Championship. The loser goes fishing.
It was a rock fight, but Sam Darnold and the Seahawks won that game three weeks ago in the regular season finale, 13-3, to secure the division and the No. 1 seed in the NFC. Darnold and the offense were good enough that afternoon in San Francisco, but the Seattle defense was the story limiting Brock Purdy and the 49ers to 173 yards of total offense. These teams also opened the season against each other. San Francisco took that meeting over the Seahawks in Seattle, 17-13. Purdy threw for 277 yards and two touchdowns, and Christian McCaffrey carried the ball 22 times for 69 yards and caught 9 passes for 73 yards.
No question the 49ers are the underdog in this game, but despite an inordinate number of injuries at wide receiver and across their defense, Kyle Shanahan’s crew is within two wins of the Super Bowl. The Niners found a way to win last week in their Wild Card game against the Eagles in Philadelphia, 23-19. Purdy threw for 262 yards and McCaffrey scored twice to pace the attack.
A couple of areas to pay attention to in this game. Seattle is T1 with the Rams in third quarter scoring (7.1 points). Defensively, they allow an average of 3.3 points in the third quarter (T6). Their halftime adjustments on both sides of the ball are elite. For the Niners, Shanahan and co. need to find a way to pressure Darnold. The pass rush has not been a strength of theirs this season, but Seattle’s offensive line has been leaky at times. The San Francisco offense may get some help with wideout Ricky Pearsall (knee/ankle) trending towards being active, but TE George Kittle (Achilles) is out.
These teams have met twice previously in the playoffs. Seattle won the 2013 NFC Championship game, 23-17. San Francisco advanced from the Wild Card round in the 2022 playoffs, 41-23.
Lets dive into the matchup a little deeper and see where the numbers, quarterbacks, and injuries take us as we seek out an advantage or two.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates courtesy of Rotoworld, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to Watch: 49ers at Seahawks
- Date: Saturday, January 17, 2026
- Time: 8PM EST
- Site: Lumen Field
- City: Seattle, WA
- Network/Streaming: FOX
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Game Odds: 49ers at Seahawks
The latest odds as of Wednesday courtesy of DraftKings:
- Moneyline: San Francisco 49ers (+280), Seattle Seahawks (-355)
- Spread: Seahawks -7
- Total: 45.5 points
This game opened at Seahawks -7 with the Game Total set at 46.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Playoff History: 49ers and Seahawks
San Francisco 49ers
All-Time Playoffs: 40-25
Wild Card Round: 7-2
Divisional Round: 20-8
NFC Championship: 8-11
Super Bowl: 5-3
Pre-1966: 0-1
Seattle Seahawks
All-Time Playoffs: 17-19
Wild Card Round: 9-7
Divisional Round: 4-9
NFC Championship: 3-1
Super Bowl: 1-2
Quarterback Matchup: 49ers at Seahawks
- 49ers Starting QB: Brock Purdy
Last Game: 1/11 at Philadelphia – 18-31, 262yds, 2TDs, 2INTs, Sacked 1 time, 9 carries for 24yds rushing
2025 Postseason: 1GP, 18-31, 262yds, 2TDs, 2INTs, Sacked 1 time, 9 carries for 24yds rushing
- Seahawks Starting QB: Sam Darnold
Last Game: 1/3 at 49ers – 20-26, 198yds, 0TDs, 0INTs, Sacked 2 times, 6 carries for 9yds rushing
Season: 17GP, 323-477, 4048yds, 25TDs, 14INTs, Sacked 27 times, 35 carries for 95yds rushing
49ers at Seahawks: Team Stats and Betting Trends
- The 49ers are 11-7 ATS this season
- The Seahawks are 12-5 ATS this season
- The 49ers are 8-2 ATS on the road this season
- The Seahawks are 4-4 ATS at home this season
- The OVER has cashed in 10 of the 49ers’ 18 games this season (10-8)
- The OVER has cashed in 9 of the Seahawks’ 17 games this season (9-8)
- No QB in the NFL has won more games than Sam Darnold the past 2 seasons (28)
- In the 2 games against the 49ers during the regular season, Darnold has thrown for just 348 total yards and 0 TDs
49ers Player Injuries
- WR Ricky Pearsall (ankle/knee) is listed as questionable for Saturday’s game
- TE George Kittle (Achilles) has been declared OUT of Saturday’s game
- LT Trent Williams (hamstring) is listed as questionable for Saturday’s game
- RG Dominick Puni (undisclosed) is listed as questionable for Saturday’s game
- LB Dee Winters (ankle) is listed as questionable for Saturday’s game
- LB Luke Gifford (quad) is listed as questionable for Saturday’s game
- S Ji’Ayir Brown (hamstring) is listed as questionable for Saturday’s game
- DE Yetur Gross-Matos (knee) is listed as questionable for Saturday’s game
- DE Keion White (undisclosed) is listed as questionable for Saturday’s game
Seahawks Player Injuries
- LT Josh Jones (knee) is listed as questionable for Saturday’s game
- CB Riq Woolen (oblique) is listed as questionable for Saturday’s game
- LB DeMarcus Lawrence (Achilles) is listed as questionable for Saturday’s game
- LB Tyrice Knight (shoulder) is listed as questionable for Saturday’s game
- TE Elijah Arroyo (knee) remains on IR but did practice Tuesday and is eligible to be activated for Saturday’s game
Rotoworld Best Bets
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the 49ers and the Seahawks
- Moneyline: Rotoworld Bet is staying away from a play on the Moneyline.
- Spread: Rotoworld Bet is recommending a play on the Seahawks -7.
- Total: Rotoworld Bet is recommending a play on the Game Total UNDER 45.5
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