The AFC South is now interesting. With a couple losses in the last three weeks, the Colts (8-3) have allowed the Jaguars (7-5) and the Texans (6-5) back into the race for the division title. Sunday in Indy, Daniel Jones and co. look to re-establish themselves as the best team in the division while putting a serious hurt in CJ Stroud and the Texans’ division and playoff push.
The Texans have won three straight and four of their last five to crawl out of Tennessee’s neighborhood and back into the playoff chase.
Adding fuel to their resurgence is the return of Stroud under center following a stint in concussion protocol.
In terms of this game’s implications in the AFC South, a win would give the Colts crucial separation from the Texans and Jaguars while a loss would allow the Jags and the Texans to pull to within a single game of Indy.
Houston has won each of the last three meetings in this rivalry.
Matchup to Watch: Colts’ elite offense vs. Texans’ dominant defense
Led by Jonathan Taylor, Indianapolis averages a league-leading 31.0 points per game. Taylor leads the league in rushing yards and touchdowns. Houston counters with the NFL’s second stingiest defense which allows just 16.5 points per game.
Lets take a deeper dive into this week’s matchup between the Texans and the Colts.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates from Rotoworld, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Texans vs. Colts live Sunday
- Date: Sunday, November 30, 2025
- Time: 1:00PM EST
- Site: Lucas Oil Stadium
- City: Indianapolis, IN
- Network/Streaming: CBS
Want to check out the other games on the NFL schedule this week? We’ve got you covered at NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!
Game odds for the Texans at the Colts
The latest odds as of Wednesday courtesy of DraftKings:
- Moneyline: Houston Texans (+195), Indianapolis Colts (-238)
- Spread: Colts -4.5
- Total: 44.5 points
This game opened at Colts -3.5 with the Game Total set at 45.0.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Houston at Indianapolis
- Texans Starting QB: C.J. Stroud
Last Game: 11/2 vs. Denver - 6-10, 79yds, 0TDs, 0INTs, Sacked 2 times, 2 carries for 12yds rushing
Season: 8GP, 161-242, 1702yds, 11TDs, 5INTs, Sacked 17 times, 29 carries for 189yds rushing - Colts Starting QB: Daniel Jones
Last Game: 11/23 at Kansas City - 19-31, 181yds, 2TDs, 0INTs, 0 Sacks, 3 carries for 16yds rushing
Season: 11GP, 242-350, 2840yds, 17TDs, 7INTs, Sacked 21 times, 43 carries for 159yds rushing
Texans at Colts team stats, betting trends
- The Colts have won 4 straight games against the AFC South
- The Colts are 6-3-2 ATS this season
- 6 of the Colts’ last 8 games against AFC South teams have gone OVER the Total
- The OVER has cashed in 3 of the Texans’ 11 games this season (3-7-1)
- Houston is 5-6 ATS this season
- Jonathan Taylor has had 172 carries for 964 yards and has scored 10 touchdowns in 8 games versus the Texans in his career
Texans Player Injuries
- C.J. Stroud (concussion) is listed as questionable for Sunday’s game
- LB Jamal Hill (hamstring) is listed as questionable for Sunday’s game
- S Jalen Pitre (concussion) is listed as questionable for Sunday’s game
- CB Ajani Carter (hamstring) is listed as questionable for Sunday’s game
- S Jimmie Ward (foot) has been declared OUT for Sunday’s game
Colts Player Injuries
- LB Jaylon Carlies (ankle) is eligible to be reinstated from the IR but has not yet been activated
- QB Anthony Richardson (eye) is eligible to be reinstated from the IR but has not yet been activated
Rotoworld Best Bets
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Texans and the Colts
- Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
- Spread: NBC Sports Bet is recommending a play ATS on the Houston Texans at +4.5.
- Total: NBC Sports Bet is staying away from a play on the Game Total of 44.5.
Rotoworld has you covered with all the latest betting info & tools for NFL with player news, game predictions, player props, futures, and trends!
Follow our experts on socials to keep up with all the latest content from the staff:
● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)
