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Fantasy Football Injury Report Week 2: 49ers in flux, Xavier Worthy, Drake London updates

Staying up to date on NFL injury news is of the utmost importance for fantasy football success. The article below tracks all fantasy-relevant players currently listed on their team’s injury report, and provides fantasy managers with actionable recommendations as new information rolls in.

Check back for updates from Tuesday through Saturday.

**UPDATED AS OF SATURDAY SEPTEMBER 13 AT 2 PM ET**

🏈 AFC East

◆ Buffalo Bills

James Cook - RB (hamstring)

Cook appeared on Wednesday’s injury report with a hamstring injury, listed as a limited participant.

Fantasy Impact: Cook was removed from the team’s injury report Friday and is clear to play against the Jets in Week 2.

Dawson Knox - TE (hip)

Knox was limited on Wednesday.

Fantasy Impact: Knox was removed from the team’s injury report Friday and is clear to play against the Jets in Week 2.

◆ Miami Dolphins

Jaylen Waddle - WR (shoulder)

Waddle was limited in Wednesday‘s practice.

Fantasy Impact: Waddle was removed from the team’s injury report Friday and will play against the Patriots in Week 2.

Darren Waller - TE (hip)

Waller remains sidelined as of Wednesday.

Fantasy Impact: Waller was ruled for Week 2 against the Patriots. Fantasy managers clinging to hope on the aging veteran can safely return Waller to the waiver wire.

Jaylen Wright - RB (knee)

Wright has not yet returned to practice, as of Wednesday.

Fantasy Impact: Wright is listed as doubtful for Week 2. Fellow Dolphins running back Ollie Gordon turned three Week 1 touches into three yards. Wright could regain the No. 2 running back role upon his return.

◆ New England Patriots

Stefon Diggs - WR (knee)

Diggs played just 41 percent of the team’s offensive snaps (29) in a Week 1 loss as he continues to ramp up his activity levels following a torn ACL in 2024.

Fantasy Impact: Fantasy managers will need to stay patient with the veteran receiver who is playing in his age-32 season. It is likely we see his snap rates continue to tick up, but you would be better off finding an alternative until we see his snap rates return to pre-injury levels.

Kayshon Boutte - WR (shoulder)

Boutte appeared on Wednesday’s injury report as a limited participant after tying for a team-high 19.0 percent target share.

Fantasy Impact: Boutte was removed from the injury report Friday and will play against the Dolphins. He is worth starting as a FLEX option after ranking fifth in the league in air yards to open the season.

◆ New York Jets

Mason Taylor - TE (ankle)

Taylor was sidelined on Wednesday and is listed questionable for Week 2 against the Bills. The rookie tight end dealt with a high-ankle sprain during training camp. Head coach Aaron Glenn said Taylor has indeed injured the same ankle, though he did not confirm whether it is specifically a re-injury. A low-ankle sprain is possible.

Fantasy Impact: Fantasy managers should expect Taylor to miss time, particularly if this is in fact a high-ankle sprain recurrence. Taylor earned just one target in Week 1, so this is unlikely to meaningfully alter team target shares.

Eric Samulski breaks down his fantasy football defense rankings for Week 2 of the NFL season

🏈 AFC North

◆ Baltimore Ravens

Isaiah Likely - TE (foot)

Likely is out for Week 2 against the Browns.

Fantasy Impact: Likely is worth stashing on benches, given tight end Mark Andrews’ Week 1 faceplant. Andrews’ 75.0 percent snap share keeps him in play as a TE1 with Likely sidelined, though things could change once the younger player returns.

◆ Cincinnati Bengals

The Bengals emerged from a narrow Week 1 win relatively unscathed.

◆ Cleveland Browns

The Browns avoided any major injuries in a Week 1 loss to the Bengals.

◆ Pittsburgh Steelers

The Steelers did not suffer any significant injuries in their Week 1 win over the Jets.

🏈 AFC South

◆ Houston Texans

Joe Mixon - RB (foot)

Mixon was placed on injured reserve ahead of Week 1 and will miss the first four weeks of the season, at minimum. He will reportedly be re-evaluated at that time.

Fantasy Impact: Earlier reports indicated veteran Nick Chubb would be utilized as a workhorse back for the Texans for as long as Mixon remained absent, but the team’s actions in Week 1 tell a different story. Chubb handled a 51 percent snap rate and 13 of the team’s 21 running back carries, good for a 61.9 percent backfield share. Mixon remains a shaky bet for fantasy leagues in 2025, while Chubb appears to be nothing more than a potential bye week flex option.

Christian Kirk - WR (hamstring)

Kirk missed Week 1 and could be out longer.

Fantasy Impact: Texans wide receivers, Xavier Hutchinson and Justin Watson, earned just two targets apiece, operating in the team’s Nos. 2 and 3 roles last week. Rookie wide receiver Jayden Higgins can be stashed on fantasy benches.

Cade Stover - TE (foot)

The Texans placed Stove on injured reserve today.

Fantasy Impact: Stover will miss at least four games. His absence should add one or two targets to tight end Dalton Schultz’s weekly workload. The uptick is not enough to make Schultz a reliable TE1.

◆ Indianapolis Colts

Michael Pittman Jr. - WR (glute)

Pittman practiced in full on Wednesday.

Fantasy Impact: This is a new injury, but Pittman’s Week 2 availability does not appear to be in jeopardy.

Alec Pierce - WR (knee)

Pierce practiced in full on Wednesday.

Fantasy Impact: This is a new injury for Pierce, but his full participation puts him on track to play in Week 2.

◆ Jacksonville Jaguars

The Jaguars’ fantasy-relevant players are healthy.

◆ Tennessee Titans

Tyjae Spears - RB (ankle)

Spears remains on injured reserve as he tends to an ankle injury suffered in the team’s first preseason game.

Fantasy Impact: Backfield mate Tony Pollard saw an 89.0 percent snap rate and handled all but two running back opportunities (18 carries and one target) for the Titans against the Broncos in Week 1. He remains a locked-in RB2 with RB1 upside for as long as Spears remains out.

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🏈 AFC West

◆ Denver Broncos

Evan Engram - TE (calf)

Engram suffered a calf injury in the fourth quarter last week and was sidelined thereafter. He was limited at Wednesday’s practice.

Fantasy Impact: Engram was removed from the team’s injury report Friday, but the veteran tight end is no longer a TE1.

◆ Kansas City Chiefs

Xavier Worthy - WR (shoulder)

Worthy has been ruled out for Week 2 against the Eagles.

Fantasy Impact: Hollywood Brown‘s 16 targets led all Chiefs pass catchers by a nine-target margin in Week 1. He is FLEX-viable in Week 2. JuJu Smith-Schuster can be stashed in PPR leagues for those willing to roll the dice. Tyquan Thornton is also worth stashing. Both players may be agonizingly unreliable.

◆ Las Vegas Raiders

Brock Bowers - TE (knee)

Bowers suffered a knee injury in the fourth quarter of the team’s Week 1 win over the Patriots. He was spotted on the sideline with his helmet on but never returned.

Fantasy Impact: Bowers is reportedly day-to-day following the injury but Seahawks head coach Pete Carroll is notoriously devious in reporting injuries, giving us some pause regarding his potential Week 2 status. Fantasy managers will want to follow the situation closely and err on the side of practice participation over coaching comments. Any missed time by Bowers would thrust wide receiver Jakobi Meyers into WR2 territory.

◆ Los Angeles Chargers

The Chargers avoided any meaningful fantasy injuries in their Week 1 win over the Chiefs.

Travis Etienne and Breece Hall had explosive performances in Week 1 and looked poised to be some of the best fantasy football values of the summer.

🏈 NFC East

◆ Dallas Cowboys

The Cowboys emerged from their Week 1 loss to the Eagles without any fantasy relevant injuries.

◆ New York Giants

Malik Nabers - WR (back)

Nabers was removed from the injury report and will play in Week 2 against the Cowboys.

Fantasy Impact: Nabers remains a fantasy WR1 after seeing 68.6% of the team’s air yards in Week 1.

Wan’Dale Robinson - WR (ankle)

Robinson is listed as questionable for Week 2 against the Cowboys.

Fantasy Impact: The PPR FLEX weapon should be available for Week 2 after two limited sessions to end the week.

◆ Philadelphia Eagles

Will Shipley - RB (oblique)

Shipley’s Week 1 injury has turned into quite the saga. The Eagles acquired running back Tank Bigsby via trade on Monday. Reports on Tuesday indicated that Shipley had fractured a rib. The team’s official injury report lists it as an oblique issue. He has been ruled out for Week 2.

Fantasy Impact: Both Bigsby and running back A.J. Dillon are candidates to replace him in the No. 2 role. Bigsby should be prioritized as a bench stash.

Dallas Goedert - TE (knee)

Goedert is out for Week 2 against the Chiefs.

Fantasy Impact: The knee sprain is not expected to be a long-term issue. Backup tight end Grant Calcaterra is the next player up. He can only be treated as a dart-throw TE2. Targets will likely shift toward the Eagles’ wide receiver trio instead.

◆ Washington Commanders

Jayden Daniels - QB (right wrist)

Daniels was removed from the injury report and will play in Week 2 against the Packers. He practiced in full all week.

Fantasy Impact: Daniels’ early-week participation suggests this is a non-issue, however, it is worth monitoring. Daniels is right-handed. He remains an elite QB1 until further notice.

Austin Ekeler - RB (Achilles)

Ekeler suffered a torn Achilles in the team’s Week 2 loss to the Packers. His season is done.

Fantasy Impact: Ekeler’s absence opens the door for increased usage for rookie Jacory Croskey-Merritt, although the team is likely to continue with a split backfield moving forward. Consider the talented rookie the best bet to return RB2 numbers the rest of the way.

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🏈 NFC North

◆ Chicago Bears

DJ Moore - WR (abdomen/groin)

Moore took a hard hit to his midsection in Week 1, but he was on the field for Wednesday’s practice and promisingly participated fully.

Fantasy Impact: Moore should be good to go for Week 2 against the Lions.

Roschon Johnson - RB (foot)

Johnson resumed practicing on Wednesday, ending his extended absence. He will play in Week 2.

Fantasy Impact: The bad news is that Bears head coach Ben Johnson said he wants to get running back Kyle Monangai more involved today. It’s unclear which running back holds the No. 2 role.

◆ Detroit Lions

The Lions emerged from their Week 1 loss to the Packers absent any major injuries.

◆ Green Bay Packers

Jayden Reed - WR (collarbone)

Reed suffered a broken collarbone in the team’s Week 2 win over the Commanders. He will be sidelined 6-8 weeks.

Fantasy Impact: Reed’s absence opened up the middle of the field for tight end Tucker Kraft, who posted a robust 6-124-1 receiving line against the Commanders. Consider Kraft a locked-in TE1 for as long as Reed remains out.

◆ Minnesota Vikings

The Vikings did not suffer any fantasy-relevant injuries in their Week 1 win over the Bears.

🏈 NFC South

◆ Atlanta Falcons

Drake London - WR (shoulder)

London was removed from the team’s injury report Friday.

Fantasy Impact: London avoided a major injury and will play in Week 2 against the Vikings as a fantasy WR1.

Darnell Mooney - WR (shoulder)

Mooney was removed from the team’s injury report and will play against the Vikings.

Fantasy Impact: Mooney should be considered a FLEX option in his first appearance of the season.

◆ Carolina Panthers

Hunter Renfrow - WR (ribs)

Renfrow was removed from the injury report Friday.

Fantasy Impact: The veteran slot receiver is no more than a shaky FLEX option.

◆ New Orleans Saints

The Saints did not experience any fantasy relevant injuries in their Week 1 loss to the Cardinals.

◆ Tampa Bay Buccaneers

Jalen McMillan - WR (neck)

McMillan remains on injured reserve with a neck injury suffered in preseason.

Fantasy Impact: McMillan’s absence paved the way for rookie wide receiver Emeka Egbuka to see featured usage in the offense right out of the gate. The talented rookie remains in the weekly WR2 discussion after dropping a 4-67-2 line against the Falcons.

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🏈 NFC West

◆ Arizona Cardinals

The Cardinals were not subject to any substantial injuries in their Week 1 win over the Saints.

◆ Los Angeles Rams

The Rams emerged from their Week 1 win over the Texans absent any fantasy-relevant injuries.

◆ San Francisco 49ers

Christian McCaffrey - RB (calf, rest)

McCaffrey was removed from the team’s injury report and will play in Week 2 against the Saints.

Fantasy impact: McCaffrey handled 31 touches while nursing the calf injury last week and is all systems go in Week 2.

George Kittle - TE (hamstring)

The 49ers placed Kittle on injured reserve Tuesday, meaning he will miss at least the next four games.

Fantasy impact: The 49ers are dealing with multiple key injuries. It is difficult to make up for Kittle’s lost production with any remaining 49ers tight end, meaning fantasy managers will want to look elsewhere until Kittle returns. Running back Christian McCaffrey and wide receiver Ricky Pearsall stand to benefit in what has become a decimated skill position group.

Brock Purdy - QB (shoulder, toe)

Purdy was ruled out for Week 2 against the Saints.

Fantasy Impact: Backup quarterback Mac Jones is not a starter in 12-team leagues, but he is certainly worth adding in two-quarterback formats. Christian McCaffrey can be expected to handle another elite workload in Week 2, with Jones under center. Jones’ successes as the Jaguars’ fill-in starter last year keep Ricky Pearsall firmly on the WR3 radar.

Jauan Jennings - WR (shoulder)

Jennings is listed as questionable in Week 2 against the Saints.

Fantasy Impact: The 49ers recently brought back wide receiver Kendrick Bourne on a one-year deal. Bourne could return WR5/FLEX value if Jennings is unable to play.

◆ Seattle Seahawks

Jake Bobo - WR (concussion)

Bobo was removed from the injury report and Will play in Week 2 against the Steelers.

Fantasy Impact: This is great news for Sam Darnold, who is in desperate need of capable pass catchers. Bobo is not on the WR4/FLEX radar, but he can help the offense move the ball downfield, which was an issue for them at times last week.