It’s Wednesday, August 6 and the Padres (62-51) are in Phoenix to take on the Diamondbacks (54-59). Nestor Cortes is slated to take the mound for San Diego against Anthony DeSclafani for Arizona.
San Diego took game two of the series, 10-5 in extras with a five-run 10th inning. The Padres are 2-2 in the last four games after winning six consecutive games, while the loss snapped a three-game winning streak for the D-Backs.
Let’s dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Padres at Diamondbacks
- Date: Wednesday, August 6, 2025
- Time: 9:40PM EST
- Site: Chase Field
- City: Phoenix, AZ
- Network/Streaming: SDPA, ARID, MLBN
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Padres at the Diamondbacks
The latest odds as of Wednesday:
- Moneyline: Padres (-147), Diamondbacks (+123)
- Spread: Padres -1.5
- Total: 9.0 runs
Probable starting pitchers for Padres at Diamondbacks
- Pitching matchup for August 6, 2025: Nestor Cortes vs. Anthony DeSclafani
- Padres: Nestor Cortes, (1-1, 9.00 ERA)
Last outing: 0.00 ERA, 0 Earned Runs Allowed, 1 Hits Allowed, 2 Walks, and 6 Strikeouts - Diamondbacks: Anthony DeSclafani, (1-2, 4.91 ERA)
Last outing: 15.43 ERA, 4 Earned Runs Allowed, 5 Hits Allowed, 3 Walks, and 0 Strikeouts
- Padres: Nestor Cortes, (1-1, 9.00 ERA)
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Expert picks & predictions for tonight’s game between the Padres and the Diamondbacks
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Wednesday’s game between the Padres and the Diamondbacks:
- Moneyline: NBC Sports Bet is recommending a play on the San Diego Padres on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the Arizona Diamondbacks at +1.5.
- Total: NBC Sports Bet is staying away from a play on the Game Total of 9.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.
Top betting trends & insights to know ahead of Padres at Diamondbacks
- Arizona is 3-1 in the last 4 games
- Arizona is 7-10 in the last 17 games
- Arizona is 5-3 versus San Diego this season
- San Diego is 2-2 in the past 4 games
- The Diamondbacks have lost 4 of their last 5 games against teams with winning records
- 4 of the Diamondbacks’ last 5 home games stayed under the Total
- The Diamondbacks have covered the Run Line in 3 straight games
If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
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- Jay Croucher (@croucherJD)
- Drew Dinsick (@whale_capper)
- Vaughn Dalzell (@VmoneySports)
- Trysta Krick (@Trysta_Krick)
