Two banged up teams looking to turn around their fortunes meet at MetLife Stadium in Week 9 when San Francisco 49ers (5-3) visit the New York Giants (2-6). The 49ers’ litany of injuries may have finally caught up with them. From Brock Purdy to the wide receiver room to the defensive line, Kyle Shanahan’s crew is a shell of what it was to be when the season began. They have lost two in a row, fallen out of first place, and now trail the Seahawks and the Rams in the NFC West. The Giants have also lost two straight, and they too are dealing with injuries to key personnel. Star wideout Malik Nabers was lost for the season a handful of weeks ago. Key members of the secondary remain hobbled and sidelined. The latest impact player to fall, rookie running back Cam Skattebo, is out for the remainder of the season.
Expect plenty of Christian McCaffrey on Sunday. New York has been terrible at stopping the run and McCaffrey remains one of the best. Yes, the 49ers are flying to the East Coast for a 1P kickoff. Yes, there is limited tape on rookie signal-caller Jaxson Dart. Giants’ fans have to hope those factors play into this game because the rosters and coaching staffs point towards a 49ers’ win.
Lets dive into the numbers and see where we might find an advantage or two.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the 49ers at the Giants live Sunday
- Date: Sunday, November 2, 2025
- Time: 1:00PM EST
- Site: MetLife Stadium
- City: East Rutherford, NJ
- Network/Streaming: CBS
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Game odds for the 49ers at the Giants
The latest odds as of Thursday courtesy of DraftKings:
- Moneyline: San Francisco 49ers (-148), New York Giants (+124)
- Spread: 49ers -2.5
- Total: 48.5 points
This game opened at 49ers -2.5 with the Game Total set at 45.0.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for San Francisco at New York
- 49ers Expected Starting QB: Mac Jones
Last Game: 10/26 at Houston - 19-32, 193yds, 2TDs, 1INT, Sacked 2 times, 2 carries for 23yds rushing
Season: 6GP, 149-226, 1597yds, 8TDs, 5INTs, Sacked 14 times, 23 carries for 57yds rushing - Giants Starting QB: Jaxson Dart
Last Game: 10/26 at Philadelphia - 14-24, 193yds, 1TD, 0INTs, Sacked 5 times, 6 carries for 17yds rushing
Season: 7GP, 85-142, 984yds, 8TDs, 3INTs, Sacked 17 times, 43 carries for 195yds rushing
49ers at Giants team stats, betting trends
- Jaxson Dart: 4 games with pass TD and rush TD this season (T-most in NFL w/ Mahomes)
- Christian McCaffrey: 2nd-most scrimmage yards this season (1,049 - 7 yds behind IND’s Jonathan Taylor) but just 68 scrimmage yards (season-low) in Week 8
- The 49ers have won 9 of their last 11 early East Coast games (1:00 pm ET kickoff)
- The 49ers are 4-4 ATS this season
- The Giants are 4-4 ATS this season
- The OVER is 4-4 in the Giants’ games last season
- The OVER is 4-3-1 in the 49ers’ games this season
49ers Player Injuries
- QB Brock Purdy (toe) is questionable for Sunday’s game
- DT Jordan Elliott (ankle) is questionable for Sunday’s game
- C Jake Brendel (hamstring) is questionable for Sunday’s game
- LT Spencer Burford (knee) was a full participant Wednesday in practice and is expected to be activated for Sunday’s game
- LG Ben Bartch (ankle) is eligible to be activated off IR this Sunday but has been limited in practice this week
- Sam Okuayinonu (ankle) is questionable for Sunday’s game
- WR Ricky Pearsall (knee) is questionable for Sunday’s game
- DE Bryce Huff (hamstring) is questionable for Sunday’s game
- DE Yetur Gross-Matos (undisclosed) is questionable for Sunday’s game
- DT Alfred Collins (undisclosed) is questionable for Sunday’s game
- LB Dee Winters (knee) is questionable for Sunday’s game
- CB Upton Stout (shoulder) is questionable for Sunday’s game
Giants Player Injuries
- CB Paulson Adebo (knee) is questionable for Sunday’s game
- S Jevon Holland (knee) is questionable for Sunday’s game
- RT Jermaine Eluemunor (pectoral) is questionable for Sunday’s game
- CB Cor’Dale Flott (concussion) is questionable for Sunday’s game
- WR Jalin Hyatt (undisclosed) is questionable for Sunday’s game
- WR Beaux Collins (quad) is questionable for Sunday’s game
- TE Daniel Bellinger (neck) is questionable for Sunday’s game
- TE Chris Manhertz (undisclosed) is questionable for Sunday’s game
- CB Art Green (hamstring) is questionable for Sunday’s game
- LB Chauncey Golston (undisclosed) is questionable for Sunday’s game
Rotoworld Best Bets
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Drew Dinsick (@whale_capper): New York Giants ML+135
Expecting the Giants to take advantage of the weak pass rush and depleted defense to stay ahead of a Niners team that will also lose in the trenches with their offense on the field.
Vaughn Dalzell (@VmoneySports): Christian McCaffrey Over 14.5 Longest Rush
The 49ers and the Saints are the only two teams in the NFL without a 20-yard run and I think that changes when the 49ers go to MetLife to take on the Giants. New York has allowed an NFL-high 18.7% of runs against them to go for 10 or more yards and CMC is looking for a bounce back after 25 rushing yards last week — I like CMC to go Over his longest rush prop.
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the 49ers and the Giants
- Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the San Francisco 49ers at -2.5.
- Total: NBC Sports Bet is recommending a play on the over on the Game Total of 48.0.
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● Jay Croucher (@croucherJD)
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● Vaughn Dalzell (@VmoneySports)
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