A banged up and shorthanded San Francisco 49ers (1-0) squad hits the gridiron Sunday in New Orleans against the Saints (0-1).
The injuries for the 49ers are mounting as Brock Purdy was added to the injury report Wednesday and is doubtful for Sunday’s game. Assuming he does not dress, Mac Jones is expected to start in his place. Earlier this week, George Kittle (hamstring) was placed on the IR.
The Saints are not as banged up as the Niners but also do not have the same level of talent and depth as San Francisco. New Orleans hung tough against the Cardinals last week before ultimately losing, 20-13. The Saints played well on defense limiting Arizona to 276 total yards (130 passing) but could not muster much offense themselves (315 total yards) and was penalized 13 times for 89 yards.
Lets take a deeper dive into this Week 2 matchup between the 49ers and the Saints.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the 49ers vs. Saints live Sunday
- Date: Sunday, September 14, 2025
- Time: 1:00PM EST
- Site: Caesars Superdome
- City: New Orleans, LA
- Network/Streaming: FOX
Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!
Game odds for the 49ers at the Saints
The latest odds as of Thursday courtesy of DraftKings:
- Moneyline: 49ers (-170), Saints (+142)
- Spread: 49ers -3
- Total: 40.5 points
This game opened 49ers -7.5 with the Game Total set at -44.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for San Francisco vs. New Orleans
- 49ers Expected Starting QB: Mac Jones
Last Game: January 5, 2024 at Indianapolis
20-32 (62.5%), 225 yards, 1 TD, 1 INT, Sacked twice, Carried the ball 5 times for 17 yards - Saints Expected Starting QB: Spencer Rattler
Last Game: September 7 vs. Arizona
27-46 (58.7%), 214 yards, 0 TDs, 0 INTs, Sacked 1 time for 6 yards, Carried the ball 4 times for 29 yards
49ers vs. Saints team stats, betting trends
- The Saints have lost 4 of their last 5 games
- The Saints failed to cover the Spread 10 times last season
- 4 of the Saints’ last 5 home games have stayed UNDER the Total
- Alvin Kamara rushed the ball 11 times for 45 yards and 1 TD last week
- Ricky Pearsall caught 4 passes for 108 yards last week
49ers Player Injuries
- QB Brock Purdy (toe) is listed as doubtful for Sunday’s game
- TE George Kittle (hamstring) was placed on the IR Tuesday and is thus out for Sunday’s game
- WR Jauan Jennings (shoulder) is listed as questionable for Sunday’s game
- G Ben Batch (undisclosed) is listed as questionable for Sunday’s game
- WR Jordan Watkins (ankle) is listed as questionable for Sunday’s game
- DE Yetur Gross-Matos (knee) is listed as questionable for Sunday’s game
Saints Player Injuries
- LG Trevor Penning (toe) is listed as questionable for Sunday’s game
- RT Taliese Fuaga (knee) is listed as questionable for Sunday’s game
- LB Chase Young (calf) is listed as questionable for Sunday’s game
- S Julian Blackmon (shoulder) has been declared out for Sunday’s game
- RB/KR Velus Jones Jr. (undisclosed) is listed as questionable for Sunday’s game
- LS Zach Wood (undisclosed) is listed as questionable for Sunday’s game
Rotoworld Bet Best Bets
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the 49ers and the Saints:
- Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the New Orleans Saints at +4.5.
- Total: NBC Sports Bet is recommending a play on the over on the Game Total of 42.0.
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