Returning from their bye week and looking to snap a two-game losing streak that has seen them fall out of first in the AFC East, the Buffalo Bills will try to turn things around in Charlotte against the Carolina Panthers, who have won three straight.
The Bills are looking to avoid their first 3-game losing streak since the end of the 2019 season
including the playoffs. They lost 3 straight from Week 16 through the Wild Card round. Meanwhile, the Panthers are looking to win four in a row for the first time since Week 6 of that same 2019 season.
This game features two of the Top 3 teams in the NFL in terms of gaining yards on the ground. Buffalo ranks first averaging 151 yards/game and Carolina is third gaining an average on 140.1 yards/game.
A reason for optimism in Carolina? The Bills are allowing 5.8 yards per rush this season, the worst mark in the NFL. The only team to allow a higher mark in a single season was the 1934 Cincinnati Reds (6.4). Chuba Hubbard and Rico Dowdle are salivating at the thought.
With Bryce Young struggling with a high ankle sprain, Andy Dalton is expected to get the start for Carolina.
Fun Fact: Bills HC Sean McDermott is 8-0 coming off a bye week, the most wins by any coach without a loss in NFL history.
Fun Fact 2: The 2025 Bills are looking to avoid becoming the first team since the 2012 Cardinals to start a season 4-0 and then lose 3 straight game.
Lets take a deeper dive into this week’s matchup between the Bills and the Panthers.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Bills at the Panthers live Sunday
- Date: Sunday, October 26, 2025
- Time: 1:00PM EST
- Site: Bank of America Stadium
- City: Charlotte, NC
- Network/Streaming: FOX
Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!
Game odds for the Bills at the Panthers
The latest odds as of Friday courtesy of DraftKings:
- Moneyline: Buffalo Bills (-360), Carolina Panthers (+285)
- Spread: Bills -7
- Total: 46.5 points
This game opened at Bills -7.5 with the Game Total set at 47.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Buffalo at Carolina
- Bills Starting QB: Josh Allen
Last Game: 10/13 at Atlanta - 15-26, 180yds, 2 TDs, 2 INTs, Sacked 4 times, 6 carries for 42yds rushing
Season: 6GP, 122-178, 1397yds, 11 TDs, 4 INTs, Sacked 12 times, 46 carries for 254yds rushing - Panthers Starting QB: Andy Dalton
Last Game: 10/19 at Jets - 4-7, 60yds, 0 TDs, 0 INTs, Sacked 1 time, 2 carries for -2yds rushing
Season: 3GP, 9-13, 118yds, 1 TD, 0 INTs, Sacked 1 time, 3 carries for -3yds rushing
Bills at Panthers team stats, betting trends
- The Bills have won 4 of their last 5 games against NFC South teams
- The Panthers are 5-0 ATS in their last 5 games as a home underdog
- The Game Total UNDER has cashed in the Bills’ last 5 games off a bye
- The Panthers are 3-0 at home this season
- Bills QB Josh Allen has 5 turnovers (4 INT, 1 fumble lost) in his last 3 games after having 0 turnovers in his previous 8 games including playoffs
- Josh Allen enters Sunday with 45 career games with a passing TD & a rushing TD, tied with Cam Newton for the most such games in NFL history
Bills Player Injuries
- DT Daquan Jones (calf) has been ruled OUT for Sunday’s game
- S Taylor Rapp (knee) has been ruled OUT for Sunday’s game
- WR Joshua Palmer (knee/ankle) has been ruled OUT for Sunday’s game
- LB Terrel Bernard (ankle) is questionable for Sunday’s game
- LB Mike Milano (pectoral) is questionable for Sunday’s game
- TE Dalton Kincaid (oblique) is questionable for Sunday’s game
Panthers Player Injuries
- QB Bryce Young (ankle) is doubtful for Sunday’s game
Rotoworld Bet Best Bets
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Drew Dinsick (@whale_capper): Carolina Panthers +7½ (-110)
The Panthers will get back key guard Damian Lewis to anchor a rushing attack that will test the LBs and safeties from Buffalo and keep this game inside one score in a likely narrow Bills win.
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Bills and the Panthers:
- Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the Carolina Panthers at +7.0.
- Total: NBC Sports Bet is recommending a play on the over on the Game Total of 46.5.
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Follow our experts on socials to keep up with all the latest content from the staff:
● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)
