With the Kansas City Chiefs’ reign atop the AFC West perhaps looking vulnerable, the Denver Broncos (1-1) and LA Chargers (2-0) meet Sunday at SoFi Stadium.
No doubt Denver believes they gave away last weekend’s game in Indianapolis. They led 28-20 midway through the third quarter and kept Daniel Jones and the Colts out of the endzone the rest of the second half but failed to score again and allowed three, Spencer Shrader field goals - the last clearing the crossbar as time expired - and the Broncos lost, 29-28.
The Chargers have looked the part of one of the NFL’s best teams through two games having knocked off the Chiefs in Brazil and the Raiders in Vegas. Justin Herbert appears to have finally taken a major step forward into the upper echelon of NFL quarterbacks controlling LA’s first two games with his arm and his legs. The veteran has yet to throw an interception while racking up 560 yards passing and five touchdowns. Herbert has also rushed 16 times for 63 yards.
Lets take a deeper dive into this AFC West tilt between the Broncos and the Chargers.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Broncos vs. Chargers live Sunday
- Date: Sunday, September 21, 2025
- Time: 4:05PM EST
- Site: SoFi Stadium
- City: Inglewood, CA
- Network/Streaming: CBS
Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!
Game odds for the Denver Broncos at the LA Chargers
The latest odds as of Sunday courtesy of DraftKings:
- Moneyline: Broncos (+130), Chargers (-155)
- Spread: Chargers -2.5
- Total: 45.5 points
This game opened at Chargers -2.5 with the Game Total set at 43.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Denver vs. Los Angeles
- Broncos Expected Starting QB: Bo Nix
Last Game: 9/14 at Indianapolis – 22-30 (73.3%), 206yds, 3 TDs, 1 INT, Was not sacked, 3 carries for 20yds
Season: 47-70 (67.1%), 382yds, 4 TDs, 3 INTs, Sacked 1 time, 11 carries for 38yds rushing - Chargers Expected Starting QB: Justin Herbert
Last Game: 9/15 at Las Vegas – 19-27 (70.4%), 242yds, 2 TDs, 0 INTs, Sacked 2 times, 9 carries for 31yds
Season: 2GP, 44-61 (72.1%), 560yds, 5 TDs, 0 INTs, Sacked 5 times, 16 carries for 63yds rushing
Denver Broncos at LA Chargers team stats, betting trends
- The Chargers won 11 of their 18 games last season
- The Chargers have covered in 4 of their last 5 games against AFC West teams
- The Over is 12-8 in the Broncos’ last 10 games on the road and the Chargers’ last 10 at home combined
Broncos Player Injuries
- TE Evan Engram (back) is listed as questionable for Sunday’s game
- LB Dre Greenlaw (quad) is listed as questionable for Sunday’s game
- S Talanoa Hufanga (chest) is listed as questionable for Sunday’s game
- LB Justin Strnad (undisclosed) is listed as questionable for Sunday’s game
Chargers Player Injuries
- WR Ladd McConkey (biceps) is listed as questionable for Sunday’s game
- TE Will Dissly (knee) is listed as questionable for Sunday’s game
- LB Daiyan Henley (illness) is listed as questionable for Sunday’s game
- CB Cam Hart (undisclosed) is listed as questionable for Sunday’s game
- CB Tarheen Still (undisclosed) is listed as questionable for Sunday’s game
- CB Elijah Molden (undisclosed) is listed as questionable for Sunday’s game
- DT Justin Eboigbe (undisclosed) is listed as questionable for Sunday’s game
- LB Khalil Mack (elbow) was placed on IR Wednesday and has been declared out of Sunday’s game
- RT Savion Washington (undisclosed) has been declared out of Sunday’s game
Rotoworld Bet Best Bets
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Broncos and the Chargers:
- Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the Denver Broncos at +2.5.
- Total: NBC Sports Bet is leaning towards a play on the under on the Game Total of 45.5.
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● Jay Croucher (@croucherJD)
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