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Falcons at Panthers prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats

With one eye on the NFC South-leading Tampa Bay Buccaneers, the Atlanta Falcons (1-1) are in Charlotte this weekend to take on the winless Carolina Panthers (0-2).

After basically a no-show in a Week 1 26-10 loss in Jacksonville to the Jaguars, Bryce Young and the Panthers may have begun to figure things out last weekend in the desert in a 27-22 loss to the Cardinals. Carolina trailed 27-3 in the third quarter but rallied with 19 unanswered points on three Bryce Young touchdown passes to make the final score respectable.

The Falcons spanked J.J. McCarthy and the Vikings, 22-6, Sunday night on NBC and Peacock. The cause for optimism in Atlanta is that they won the game with a suffocating defense. Through two weeks the Falcons have allowed just 29 points. That stingy defense has afforded the Falcons’ offense (averaging 21 points per game) and Michael Penix Jr. to find their footing. The second-year signal-caller has thrown but one touchdown pass but has also not yet thrown an interception.

Lets take a deeper dive into this Week 3 matchup between the Atlanta Falcons and the Carolina Panthers.

NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.

Game Details and How to watch the Atlanta Falcons and the Carolina Panthers live Sunday

  • Date: Sunday, September 21, 2025
  • Time: 1:00PM EST
  • Site: Bank of America Stadium
  • City: Charlotte, NC
  • Network/Streaming: FOX

Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!

Game odds for the Falcons at the Panthers

The latest odds as of Tuesday courtesy of DraftKings:

  • Moneyline: Falcons (-250), Panthers (+205)
  • Spread: Falcons -6.0
  • Total: 43.5 points

This game opened at Falcons -2.5 with the Game Total set at 44.5.

Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!

Quarterback Matchup for Atlanta at Carolina

  • Atlanta Starting QB: Michael Penix Jr.
    Last Game: 9/14 at Minnesota - 13-21 (61.9%), 135yds, 0 TDs, 0 INTs, Sacked 3 times, 1 carry for -1 yard
    Season: 2GP, 40-63 (63.5%), 433yds, 1 TD, 0 INTs, Sacked 4 times, 7 carries for 20yds
  • Carolina Starting QB: Bryce Young
    Last Game: 9/14 at Arizona - 35-55 (63.6%), 328yds, 3 TDs, 1 INT, Sacked 3 times, 2 carries for 2yds
    Season: 2GP, 53-90 (58.9%), 482yds, 4 TDs, 3 INTs, Sacked 4 times, 7 carries for 42yds

Atlanta Falcons at Carolina Panthers team stats, betting trends

  • The Falcons are allowing an average of just 14.5 points per game
  • The Panthers are 4-1 against the spread in their last 5 games at home
  • The Panthers’ last 4 games have gone over the Total
  • Bryce Young is averaging just 5.4 yards per pass attempt

Falcons Player Injuries

  • CB A.J. Terrell Jr. (hamstring) is listed as questionable for Sunday’s game
  • OT Jack Nelson (undisclosed) is listed as questionable for Sunday’s game
  • WR Jamal Agnew (undisclosed) is listed as questionable for Sunday’s game
  • WR Casey Washington (undisclosed) is listed as questionable for Sunday’s game
  • S Jordan Fuller (knee) has been placed on IR and has been declared out of Sunday’s game

Panthers Player Injuries

  • G Robert Hunt (biceps) was placed on IR Monday and has been declared out of Sunday’s game
  • C Austin Corbett (knee) was placed on IR Monday and has been declared out of Sunday’s game
  • DT Tershawn Wharton (undisclosed) is listed as questionable for Sunday’s game
Is it time to worry about Thomas, Hunter?
Matthew Berry, Jay Croucher and Connor Rogers take a look at the Jaguars fantasy situation after an underwhelming showing from Brian Thomas Jr. and Travis Hunter.

Rotoworld Bet Best Bets

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Drew Dinsick (@whale_capper): Game Total OVER 43 (-111)

The Falcons come into this contest without CB1 AJ Terrell and will find it more difficult than expected to stop the Panthers here. The Panthers defense on the other hand is drawing dead against Bijan Robinson and company setting up a potential shootout.

***

Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Best bets our model is projecting for this week’s game between the Falcons and the Panthers:

  • Moneyline: NBC Sports Bet is leaning towards a play on the Carolina Panthers on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the Carolina Panthers at +4.5.
  • Total: NBC Sports Bet is recommending a play on the over on the Game Total of 43.0.

Rotoworld has you covered with all the latest betting info & tools for NFL with player news, game predictions, player props, futures, and trends!

Follow our experts on socials to keep up with all the latest content from the staff:

● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)