Week 5 of the NFL season opens tonight in Southern California with first place on the line in the NFC West when the San Francisco 49ers (3-1) minus Brock Purdy take the field at SoFi Stadium against the Los Angeles Rams (3-1).
The Niners laundry list of injuries has grown yet again as Purdy (toe) has been declared out of tonight’s game. San Francisco continues to be one of the larger MASH units in the league. In addition to their issues under center as many as five wide receivers and a couple of cornerbacks could miss tonight’s game and the defense remains minus Nick Bosa.
This past weekend Trevor Lawrence and the Jaguars handed Kyle Shanahan’s banged-up squad their first loss. Jacksonville jumped out to a 17-6 lead at halftime and the 49ers really never threatened a comeback in the second half.
The Rams improved to 3-1 with a 27-20 win at home over Daniel Jones and the Indianapolis Colts last weekend. LA trailed by a touchdown with under four minutes to play in the fourth quarter but rallied for two late TDs and subsequently, the victory. Matthew Stafford threw for 375 yards and three touchdowns in the win. Puka Nacua was a frequent target for Stafford catching 13 balls for 170 yards and a score in the win. With 42 catches, Nakua has tied the record for most receptions in the first four games of a season.
Lets take a deeper dive into this NFC West tilt between the San Francisco 49ers and the Los Angeles Rams.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the San Francisco 49ers and the Los Angeles Rams live Thursday
- Date: Thursday, October 2, 2025
- Time: 8:15P ET
- Site: SoFi Stadium
- City: Los Angeles, CA
- TV/Streaming: Amazon Prime Video
Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!
Game odds for the 49ers at the Rams
The latest odds as of Thursday courtesy of DraftKings:
- Moneyline: San Francisco 49ers (+350), Los Angeles Rams (-455)
- Spread: Rams -8.5
- Total: 44.5 points
This game opened Rams -3 with the Game Total set at 47.0.
Be sure to check out DraftKings for all the latest game odds & player props for every
matchup this week on the NFL schedule!
Quarterback Matchup for San Francisco at Los Angeles
- 49ers Expected Starting QB: Mac Jones
Last Game: 9/21 vs. Arizona - 27-41, 284yds, 1 TD, 1 INT, Sacked 1 time, 1 carry for -1yds
Season: 2GP, 53-80, 563yds, 4 TDs, 1 INTs, Sacked 4 times, 7 carries for 5yds - Rams Expected Starting QB: Matthew Stafford
Last Game: 9/28 vs. Indianapolis - 29-41, 375yds, 3 TDs, 0 INTs, Sacked 3 times, 4 carries for 4yds
Season: 4GP, 92-136, 1114yds, 8 TDs, 2 INTs, Sacked 8 times, 10 carries for -4yds
San Francisco 49ers at LA Rams team stats, betting trends
- The Rams are 3-1 ATS this season
- The 49ers are 2-2 ATS this season
- Rams’ Game Totals are 2-2 to the OVER this season
- 49ers’ Game Totals are 2-2 to the OVER this season
49ers Player Injuries
- S Malik Mustapha (knee) has been declared out of Thursday’s game
- WR Jauan Jennings (shoulder/ankle) has been ruled OUT of Thursday’s game
- QB Brock Purdy (toe) has been ruled OUT of Thursday’s game
- WR Ricky Pearsall (knee) has been ruled OUT of Thursday’s game
- CB Renardo Green neck) is listed as questionable for Thursday’s game
- DT CJ West (undisclosed) has been declared out of Thursday’s game
- WR Jordan Watkins (knee) has been declared out of Thursday’s game
Rams Player Injuries
- CB Ahkello Witherspoon (collarbone) remains on the IR and is OUT for Thursday’s game
- LB Keir Thomas (undisclosed) remains on the IR and is OUT for Thursday’s game
- WR Davante Adams (hamstring) is listed as questionable for Thursday’s game
- LG Steve Avila (ankle) is listed as questionable for Thursday’s game
- RT Rob Havenstein (ankle) is listed as questionable for Thursday’s game
Rotoworld Best Bets
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Drew Dinsick (@whale_capper): TOTAL u47 (-107)
Best of luck to Mac Jones in his state against this outstanding pass rush. Rams can win an ugly low-scoring contest here against the battered Niners.
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for tonight’s game between the San Francisco 49ers and the Los Angeles Rams:
- Moneyline: NBC Sports Bet is recommending a play on the Rams on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play on the Rams laying the 8.5 points
- Total: NBC Sports Bet is leaning towards a play on the Game Total UNDER 44.5 points.
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