Sunday in Houston AFC contenders collide as Josh Allen and the Buffalo Bills take on the C.J. Stroud Houston Texans. It’s a matchup between one of the NFL’s top quarterbacks and one of the league’s top defenses.
In 2026, the Bills once again finished among the AFC’s elite teams with a record of 12-5, but it was not enough to save Sean McDermott. Buffalo has handed the keys to the franchise to former offensive coordinator Joe Brady. Why Brady? Josh Allen likes him, Buffalo led the NFL in rushing yards, and the Bills are one of the most efficient red-zone teams in football. Houston reached the playoffs for a third consecutive season last year after finishing the regular season 10-7. Despite injuries and major offensive line issues throughout the year, C.J. Stroud was good enough and the Texans’ defense was elite ranking No. 1 in the entire NFL allowing just 277.2 yards per game.
We alluded to the game’s key matchup earlier. It is Josh Allen vs. the Texans’ defense. The MVP has struggled against Houston. He is 1-4 all-time against DeMeco Ryans and the Texans including 0-4 in Houston. In those five career games, Allen has thrown for 980 yards, three touchdowns, three interceptions, and recorded a passer rating of 72.7. Often forced out of the pocket, Allen has rushed for 201yds on 37 carries. The Bills’ signal-caller has also been sacked 17 times in those contests.
These teams last met on November 20, 2025 with Houston winning at home, 23-19. In that game, Josh Allen was sacked eight times and forced two interceptions of the All-Pro.
Expect a physical, playoff-style game that comes down to a handful of possessions in the fourth quarter. Points will be at a premium.
Let’s dive into the numbers and see if we can’t find an additional sweat or two.
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Game details and how to watch Bills vs. Texans
- Date: Sunday, September 13, 2026
- Time: 1PM ET
- Site: Reliant Stadium
- City: Houston, TX
- TV/Streaming: CBS
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Latest Game Odds for Bills vs. Texans
The latest odds as of Wednesday courtesy of DraftKings:
- Moneyline: Buffalo Bills (-118), Houston Texans (-102)
- Spread: Bills -1.5
- Total: 44.5
This game opened with the Bills favored by a point and a half and the O/U down one point, currently sitting at 44.5.
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Rotoworld Bet Best Bets
Expert picks & predictions for Bills vs. Texans
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, betting trends, and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Sunday’s game between the Bills and the Texans:
- Moneyline: Rotoworld Bet is leaning towards a play on the Texans on the Moneyline
- Spread: Rotoworld Bet is leaning on a play on the Texans +1.5 ATS.
- Total: Rotoworld Bet is recommending a play on the Total UNDER 44.5.
Bills vs. Texans betting trends and stats
- The Bills were 9-10 against the spread this season
- The Texans were 10-9 against the spread last season
- Buffalo was 10-8-1 to the OVER last season
- Houston was 7-11-1 to the OVER last season
Quarterback matchup for Bills vs. Texans
- Buffalo: Josh Allen
2025 Statistics: 17GP, 3668 Passing Yards, 25 TDs, 10 INTs, 102.2 Passer Rating - Houston: C.J. Stroud
2025 Statistics: 14GP, 3041 Passing Yards, 19 TDs, 8 INTs, 92.9 Passer Rating
Top Playmakers: Bills vs. Texans
Buffalo
D.J. Moore
- 2025 Statistics: 17GP, 50 Receptions on 85 Targets for 682 Yds, 6 TDs
James Cook III
- 2025 Statistics: 17GP, 309 carries for 1621 Yds, 12 TDs
Houston
David Montgomery
- 2025 Statistics: 17GP, 158 carries for 716 Yds, 8 TDs
Nico Collins
- 2025 Statistics: 15GP, 71 Receptions on 120 Targets for 1117 Yds, 6 TDs
Bills vs. Texans Injury Update
Bills
- WR Khalil Shakir (undisclosed) is listed as questionable for Sunday’s game
- WR Keon Coleman (foot) is listed as questionable for Sunday’s game
- WR Tyrell Shavers (undisclosed) is listed as questionable for Sunday’s game
- LT Jude Bowry (undisclosed) has been placed on IR with a designation to return
- LB Michael Hoecht (undisclosed) is listed as questionable for Sunday’s game
- RB Ty Johnson (lower leg) is listed as questionable for Sunday’s game
Texans
- WR Jaylin Noel (undisclosed) is listed as questionable for Sunday’s game
- DE Jadeveon Clowney (undisclosed) has been declared OUT of Sunday’s game
- LB Jake Hanse (undisclosed) is questionable for Sunday’s game
- LB Wade Woodaz (undisclosed) is questionable for Sunday’s game
- FS M.J. Stewart (quad) has been declared OUT of Sunday’s game
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