Skip navigation
Favorites
Sign up to follow your favorites on all your devices.
Sign up
Odds by

Bears vs. Lions 2025 NFL Week 2 prediction: Odds, expert picks, QBs, injury update, betting trends, and stats

Sunday in Motown the Bears (0-1) and the Lions (0-1) square off with the loser looking at an uphill climb if they hope to qualify for the postseason.

Chicago arrives in Detroit after giving up 21 fourth quarter points and losing to JJ McCarthy and the Minnesota Vikings, 27-24.
Pressure continues to mount on last year’s top overall pick, Caleb Williams. The former USC Trojan threw for 210 yards, but his average per attempt was just six yards, as he failed to see open receivers deep on a number of occasions and in the words of Troy Aikman, “just let it rip”.

The Lions were dominated at Lambeau Field Sunday afternoon, losing 27-13 to Micah Parsons and the Green Bay Packers. Detroit gained 246 yards while allowing 266. A big difference, though, was efficiency in the Red Zone. Chicago was just 1-4 while Green Bay was 3-5.

Lets take a deeper dive into this week’s matchup between these NFC North rivals.

NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.

Game Details and How to watch the Bears at the Lions live Sunday

  • Date: Sunday, September 14, 2025
  • Time: 1:00PM EST
  • Site: Ford Field
  • City: Detroit, MI
  • Network/Streaming: FOX

Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!

Game odds for the Bears at the Lions

The latest odds as of Wednesday courtesy of DraftKings:

  • Moneyline: Chicago Bears (+205), Detroit Lions (-250)
  • Spread: Lions -5.5
  • Total: 46.5 points

This game opened Lions -4.5 with the Game Total set at 48.5.

Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!

Quarterback Matchup for Chicago vs. Detroit

  • Chicago Bears Starting QB: Caleb Williams
    Last Game: September 8 vs. Minnesota
    21-35 (60%), 210 yards, 1 TD, 0 INTs, Sacked twice for 12 yards, 6 carries for 58 yards including 1 TD
  • Detroit Lions Starting QB: Jared Goff
    Last Game: September 7 at Green Bay
    31-39 (79.5%), 225 yards, 1 TD, 1 INT, Sacked 4 times totaling 25 yards, 1 carry for -1 yards

Chicago Bears at Detroit Lions team stats, betting trends

  • The Lions have won 10 of their last 11 home games against divisional opponents
  • The Bears have failed to cover the Spread in 7 of their last 10 road games
  • The Over is 4-1 in the Lions’ last 5 games against NFC teams dating back to last season
  • Jahmyr Gibbs picked up 19 yards on 9 carries and 31 yards as the result of 10 catches in Green Bay
  • Rome Odunze had 6 catches on 9 targets for 37 yards and 1 TD against Minnesota
Williams’ speed will be a ‘weapon’ for Johnson
Mike Florio and Devin McCourty shed light on why Caleb Williams’ first look in a Ben Johnson offense was “encouraging.”

Bears Player Injuries

  • LB T.J. Edwards (hamstring) is questionable for Sunday’s game
  • CB Jaylon Johnson (groin) is questionable for Sunday’s game
  • CB Kyler Gordon (hamstring) is questionable for Sunday’s game

Lions Player Injuries

  • CB Terrion Arnold (groin) is questionable for Sunday’s game
  • FS Daniel Thomas (hand) is questionable for Sunday’s game
  • OT Jamarco Jones (ankle) has been placed on IR and is out for the season
  • Backup LG Miles Frazier (undisclosed) is questionable for Sunday’s game

Rotoworld Bet Best Bets

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Vaughn Dalzell (@VmoneySports): Lions 1Q Team Total Over 5.5 (-118)

Dan Campbell and the Lions have been terrific ATS off a loss, but with the spread moving from -3.5 and -4.5 in some spots to -6 or -6.5 -- I have to pass. My favorite bet is the Lions First Quarter Team Total Over 5.5 (-118), meaning Detroit has to score six or more points in the first quarter. In the last 10 regular season games coming off a loss, Detroit has averaged 8.1 1Q PPG and scored at least one touchdown six time, three points twice with two zero-point first quarter efforts. I like the chances Detroit gets on the board early versus a Bears team coming off an embarrassing fourth quarter effort against the Vikings.

***

Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Best bets our model is projecting for this week’s game between the Bears and the Lions:

  • Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the Chicago Bears at +5.5.
  • Total: NBC Sports Bet is recommending a play on the under on the Game Total of 47.0.

Rotoworld has you covered with all the latest betting info & tools for NFL with player news, game predictions, player props, futures, and trends!

Follow our experts on socials to keep up with all the latest content from the staff:

● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)