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Chiefs vs. Titans prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats

For the first time under Head Coach Andy Reid, the Kansas City Chiefs (6-8) will be playing in a regular season game eliminated from the playoff contention this Sunday when they take the field in Nashville against Cam Ward and the Tennessee Titans.

This is the second time the Chiefs have missed the playoffs under Reid (2014). As most of humanity knows, the Chiefs take the field Sunday without Patrick Mahomes who underwent surgery this week to repair a torn ACL & LCL. Gardner Minshew will be under center for Reid and co. This will be the fifth team Minshew has started for in his career (Jacksonville, Philadelphia, Indianapolis, and Las Vegas).

The Titans could be no further from the playoffs. Tennessee is tied for the worst record in the NFL with the Giants and the Raiders. The primary reason for their failures have been due to a dreadful offense. Rookie Cam Ward and co. have scored just 225 points through 14 games (16pts/gm). Only the Raiders (196) have scored fewer points. Ward has been better of late throwing 2+ touchdown passes in back-to-back games after not throwing multiple TDs in any of his first 12 games. Maybe that is part of the reason why the line for Sunday’s game has dropped from the Chiefs favored by 11.5 to just 3.5 since Mahomes’ injury.

A couple extra tidbits before we dive deeper into the numbers:

  • Kansas City is looking to avoid their first 4-game losing streak since 2017 - the season before Mahomes took over as the full-time starter
  • Tennessee is the only team without a win at home this season (0-7)
  • Tennessee has lost 11 straight home games, tied for the 2nd longest streak in team history (lost 13 straight from 1972-73 when they were the Houston Oilers)

NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates courtesy of Rotoworld, and of course our predictions and best bets for the game from our staff of experts.

Game Details and How to Watch the Chiefs vs. Titans live Sunday

  • Date: Sunday, December 21, 2025
  • Time: 1:00PM EST
  • Site: Nissan Stadium
  • City: Nashville, TN
  • Network/Streaming: CBS

Want to check out the other games on the NFL schedule this week? We’ve got you covered at NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!

Game Odds: Chiefs at Titans

The latest odds as of Friday courtesy of DraftKings:

  • Moneyline: Kansas City Chiefs (-180), Tennessee Titans (+150)
  • Spread: Chiefs -3
  • Total: 37.5 points

This game opened at Chiefs -11.5 with the Game Total set at 41.5.

Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!

Quarterback Matchup: Kansas City at Tennessee

  • Chiefs Starting QB: Gardner Minshew
    Last Game: 12/14 vs. Chargers - 3-5, 22yds, 0TDs, 1INT, 0 Sacks, 0 carries:
    Season: 3GP, 3-5, 22yds, 0TDs, 1INT, 0 Sacks, 5 carries for -6yds rushing
  • Titans Starting QB: Cam Ward
    Last Game: 12/14 at San Francisco - 18-29, 170yds, 2TDs, 0INTs, 0 Sacks, 1 carry for 2yds rushing
    Season: 14GP, 278-469, 2638yds, 11TDs, 7INTs, Sacked 49 times, 31 carries for 129yds rushing
How Rice's injury shakes up KC offense in fantasy
Patrick Daugherty and Denny Carter unpack Rashee Rice's concussion injury for the Kansas City Chiefs and determine which other offensive players can see an uptick in targets against the Titans.

Chiefs at Titans: Team Stats and Betting Trends

  • The Chiefs are 5-8-1 ATS this season
  • The OVER has cashed in just 4 of the Chiefs’ 14 games this season (4-10
  • The Titans are 6-7-1 ATS this season
  • The OVER has cashed in 9 of the Titans’ 14 games this season)

Chiefs Player Injuries

  • QB Patrick Mahomes (knee) has been placed on IR and declared OUT for Sunday’s game
  • WR Rashee Rice (concussion) is listed as questionable for Sunday’s game
  • CB Trent McDuffie (knee) is listed as questionable for Sunday’s game
  • DT Derrick Nnadi (illness) is listed as questionable for Sunday’s game
  • WR Tyquan Thornton (concussion) is listed as questionable for Sunday’s game
  • OT Jaylon Moore (knee) is listed as questionable for Sunday’s game
  • DT Chris Jones (hamstring) is listed as questionable for Sunday’s game
  • LB Leo Chenal (shoulder) is listed as questionable for Sunday’s game

Titans Player Injuries

  • WR Van Jefferson (back) is listed as questionable for Sunday’s game
  • TE Gunner Helm (toe) is listed as questionable for Sunday’s game
  • RG Kevin Zeitler (groin) is listed as questionable for Sunday’s game
  • LB Cedric Gray (concussion) is listed as questionable for Sunday’s game
  • S Amani Hooker (illness) is listed as questionable for Sunday’s game
  • CB Jalyn Armour-Davis (undisclosed) is listed as questionable for Sunday’s game
  • LB Oluwafemi Oladejo (leg) is eligible to return from the IR this Sunday

Rotoworld Best Bets

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Best bets our model is projecting for this week’s game between the Chiefs and the Titans

  • Moneyline: RotoworldBet is leaning towards a play on the Tennessee Titans on the Moneyline.
  • Spread: Rotoworld Bet is leaning towards a play ATS on the Tennessee Titans at +3.
  • Total: Rotoworld Bet is leaning towards a play on the OVER on the Game Total of 37.5.

Rotoworld has you covered with all the latest betting info & tools for NFL with player news, game predictions, player props, futures, and trends!

Follow our experts on socials to keep up with all the latest content from the staff:

● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)