Skip navigation
Favorites
Sign up to follow your favorites on all your devices.
Sign up
Odds by

Cleveland Browns at Detroit Lions prediction: Odds, expert picks, QBs, injury update, betting trends, stats

It was a rock fight, but the Cleveland Browns (1-2) pulled possibly the upset of the season last weekend knocking off the Green Bay Packers at Huntington Bank Field, 13-10. Sunday, they look to even their record when the take on the Detroit Lions (3-1) in Motown.

The Lions opened the season with a new offensive and a new defensive coordinator and were promptly smacked by the aforementioned Packers in Week 1, 27-13, but appear to have righted the ship with subsequent wins over the Bears (52-21) and the Ravens (38-30). Jared Goff is completing nearly 80% of his passes and has not been sacked since that Week 1 loss. Speaking of sacks, the Lions’ defense had seven against Lamar Jackson this past Sunday Night.

A couple of questions to consider:
-If the Lions got to Lamar Jackson 7 times, how often will they take down Joe Flacco?
-Can the Browns slow down a Lions’ offense averaging 34pts/gm enough to allow its anemic offense (averaging less than16pts/gm) an opportunity to win the game?

Lets take a deeper dive into this week’s matchup between the Cleveland Browns and the Detroit Lions.

NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.

Game Details and How to watch Cleveland at Detroit live Sunday

  • Date: Sunday, September 28, 2025
  • Time: 1:00PM EST
  • Site: Ford Field
  • City: Detroit, MI
  • Network/Streaming: FOX

Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!

Game odds for the Browns at the Lions

The latest odds as of Sunday courtesy of DraftKings:

  • Moneyline: Cleveland Browns (+390), Detroit Lions (-520)
  • Spread: Lions -10
  • Total: 44.5 points

This game opened at Lions -10.5 with the Game Total set at 46.5.

Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!

Trust RBs Jeanty, Brown in Week 4 amid struggles
Ashton Jeanty and Chase Brown have been among fantasy's biggest early disappointments. Matthew Berry shares why managers should stick with both running backs in Week 4 lineups, who remain top-25 plays at the position.

Quarterback Matchup for Cleveland at Detroit

  • Browns Expected Starting QB: Joe Flacco
    Last Game: 9/21 vs. Green Bay – 21-36 (58.3%), 142yds, 0 TDs, 1 INT, Sacked 2 times,
    Season: 3GP, 77-126 (61.1%), 631yds, 2 TDs, 4 INTs, Sacked 6 times, 3 carries for 14yds
  • Lions Expected Starting QB: Jared Goff
    Last Game: 9/22 at Baltimore – 20-28 (71.4%), 202yds, 1 TD, 0 INTs, Was not Sacked, 4 carries for 6yds
    Season: 3GP, 74-95 (77.9%), 761yds, 7 TDs, 1 INT, Sacked 4 times, 6 carries for 11yds

Browns at Lions team stats, betting trends

  • The Lions have won 4 of their last 5 games against AFC teams
  • The Browns failed to cover 7 times on the road last season
  • The Under is 4-1 in the Browns’ last 5 games

Browns Player Injuries

  • RT Jack Conklin (undisclosed) is listed as questionable for Sunday’s game
  • DT Mike Hall Jr. (undisclosed) is listed as questionable for Sunday’s game
  • DT Shelby Harris (undisclosed) is listed as questionable for Sunday’s game

Lions Player Injuries

  • G Miles Frazier (undisclosed) has been declared out for Sunday’s game
  • RB Sione Vaki (groin) is listed as questionable for Sunday’s game
  • DE Marcus Davenport (chest) was placed on IR Monday and has been declared OUT of Sunday’s game

Rotoworld Bet Best Bets

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Best bets our model is projecting for this week’s game between the Browns and the Lions:

  • Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the Cleveland Browns at +8.5.
  • Total: NBC Sports Bet is recommending a play on the under on the Game Total of 45.0.

Rotoworld has you covered with all the latest betting info & tools for NFL with player news, game predictions, player props, futures, and trends!

Follow our experts on socials to keep up with all the latest content from the staff:

● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)