49ers released CB Willie Middlebrooks, DE Tony Brown, LB Ray Wells, G Scott Peters, CB Rayshun Reed, LB Richard Seigler, CB Allan Amundson, T Brendan Darby, C Norm Katnik, T Tim Provost and LB Matt Yates, FB Tony Ficklin, WR Marcus Maxwell, RB Bobby Purify and CB Daven Holly.
Rashaun Woods, Fred Amey and P.J. Fleck all made the team at wide receiver. Middlebrooks was a first-round pick in 2001 but his time in the league could be close to done.