Commanders at Packers NFL Week 2 prediction: Odds, expert picks, QBs, injury update, trends, and stats

After impressive performances in Week 1, the Washington Commanders (1-0) and the Green Bay Packers (1-0) meet Thursday Night at Lambeau Field.

No surprise that the Commanders opened the season with a home win against the Giants last Sunday, but the fact they controlled the game basically start to finish surprised many. The final score was 21-6 and the stats that jump off the page include Washington’s defense holding New York to 74 yards rushing on 23 attempts and the Giants gaining the Red Zone just twice in the game. Are the Giants worse than expected or are the Commanders that much better defensively than a season ago?

The most impressive aspect of the Packers’ 27-13 win this past weekend against the Lions was their ability to make the big play on offense and to make the timely play on defense. It allowed them to go 3-5 in the Red Zone on offense while limiting Detroit to one touchdown on the afternoon.

Lets take a deeper dive into this week’s matchup between the Washington Commanders and the Green Bay Packers.

NBC Sports and Rotoworld have all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.

Game Details and How to watch the Commanders vs. Packers live Thursday Night

• Date: Thursday, September 11, 2025
• Time: 8:15PM EST
• Site: Lambeau Field
• City: Green Bay, WI
• Network/Streaming: Amazon Prime Video

Want to check out the other games on the NFL schedule this week? We’ve got you covered at NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!

Game odds for the Commanders vs the Packers

The latest odds as of Tuesday courtesy of DraftKings:

• Moneyline: Washington Commanders (+150), Green Bay Packers (-180)
• Spread: Packers -3.5 (-105)
• Total: 48.5 points

This game opened with the Packers laying 2.5 points with the Game Total set at -48.5.

Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!

Parsons, LaFleur shine as Packers pound Lions

From Micah Parsons dominating on limited snaps to Matt LaFleur scheming up a storm, the Packers had a great opener against the Lions at Lambeau Field.

Quarterback Matchup for Washington at Green Bay

• Commanders Starting QB: Jayden Daniels
  Last Game: September 7 vs. Giants
  19-30 (63.3%), 233 yards, 1 TD, 0 INTs, Sacked 3 times for 21 yards, Rushed 11 times for 68 yards
• Packers Starting QB: Jordan Love
  Last Game: September 7 vs. Detroit
  16-22 (72.7%), 188 yards, 2 TDs, 0 INTs, Was not Sacked, Rushed 3 times for 4 yards

Commanders at Packers team stats, betting trends

• The Packers have won three straight at Lambeau Field against the Commanders
• The Commanders went 12-7-1 against the spread last season
• The Over was 7-4 in the Commanders’ road games last season
• Josh Jacobs rushed for 66 yards in Week 1
• Deebo Samuel rushed for 19 yards and 1 TD and caught 7 balls for 77 yards Sunday

Commanders Player Injuries

• RB Austin Ekeler (shoulder) is questionable for Thursday’s game
• WR Noah Brown (knee) is questionable for Thursday’s game
• P Tress Way (back) is questionable for Thursday’s game

Packers Player Injuries

• WR Jayden Reed (foot) is questionable for Thursday’s game
• WR Matthew Golden (ankle) is questionable for Thursday’s game
• T Zach Tom (oblique) is questionable for Thursday’s game
• G Aaron Banks (ankle/groin) is questionable for Thursday’s game
• DE Micah Parsons (back) is questionable for Thursday’s game
• CB Nate Hobbs (knee) is questionable for Thursday’s game
• WR Dontayvion Wicks (calf) is questionable for Thursday’s game

Rotoworld Bet Best Bets

'Exercise patience' with NFC north futures bets

With the NFC north all playing each other in Week 1, Trysta Krick and Drew Dinsick react to the odds of NFC North Champions and stress the need to wait for more division results before jumping on the Packers or Vikings.

Drew Dinsick (@whale_capper): Washington Commanders +3.5 (-113)

Commanders not getting nearly the respect they deserve coming into this contest at full strength on a short week. Many of the game plan aspects that worked against the Giants can be readily deployed on Thursday and capturing the hook on 3 is a solid value considering the overreactions to the Packers big win. Jayden Daniels is a big game hunter and here’s hoping he will remember his first experience in Lambeau fondly, playoff seeding likely on the line.

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Best bets our model is projecting for this Thursday’s game between the Commanders and the Packers:

• Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Washington Commanders at +3.5.
• Total: NBC Sports Bet is recommending a play on the under on the Game Total of 48.0.

Rotoworld has you covered with all the latest betting info & tools for NFL with player news, game predictions, player props, futures, and trends!

Follow our experts on socials to keep up with all the latest content from the staff:

● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)