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Saints vs. Seahawks prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats

The Seattle Seahawks (1-1) look to build on last week’s win over the Steelers as they welcome the winless New Orleans Saints (0-2) to Lumen Field Sunday afternoon.

After struggling to move the ball against the 49ers in Week 1, Sam Darnold and co. moved the ball up and down the field against the Steelers totaling 395 yards scoring twice in three trips inside the Red Zone. No doubt the expectation is Seattle will build on that performance at home against New Orleans.

The Saints have come up just short in each of their first two games suffering narrow losses to the Cardinals (20-13) and the 49ers (26-21). Spencer Rattler has been statistically solid under center throwing for 421 yards and three touchdowns without an interception.

One stat that may speak to the difference between these teams is quarterbacks’ average per attempt. Darnold is averaging 7.9 yards per attempt and Rattler 5.3. Doesn’t sound like much of a difference but how often does a possession come up 2-3 yards short of moving the chains?

Fun Fact: New Orleans has won each of the last four games against Seattle.

Lets take a deeper dive into this West Coast Week 3 matchup between the Saints and the Seahawks.

NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.

Game Details and How to watch the New Orleans Saints at the Seattle Seahawks live Sunday

  • Date: Sunday, September 21, 2025
  • Time: 4:05PM EST
  • Site: Lumen Field
  • City: Seattle, WA
  • Network/Streaming: CBS

Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!

Game odds for the Saints vs the Seahawks

The latest odds as of Sunday courtesy of DraftKings:

  • Moneyline: New Orleans Saints (+320), Seattle Seahawks (-410)
  • Spread: Seahawks -7.5
  • Total: 41.5 points

This game opened at Seahawks -6.5 with the Total set at 41.5.

Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!

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Quarterback Matchup for New Orleans at Seattle

  • Saints Starting QB: Spencer Rattler
    Last Game: 9/14 vs. San Francisco - 25-34 (73.5%), 207yds, 3 TDs, 0 INTs, Sacked 3 times, 4 carries for 14yds
    Season: 2GP, 52-80 (65%), 421yds, 3 TDs, 0 INTs, Sacked 4 times, 8 carries for 43yds
  • Seahawks Starting QB: Sam Darnold
    Last Game: 9\/14 at Pittsburgh - 22-33 (66.7%), 295yds, 2 TDs, 2 INTs, Sacked 2 times
    Season: 2GP, 38-56 (67.9%), 445yds, 2 TDs, 2 INTs, Sacked 3 times, 2 carries for 14yds

Rotoworld has you covered with all the latest betting info & tools for NFL with player news, game predictions, player props, futures, and trends!

Saints at Seahawks team stats, betting trends

  • The Saints have won 4 straight games against the Seahawks
  • The Seahawks were 2-7 at home against the spread last season
  • The Under is 4-1 in the Saints’ last 5 games against NFC teams
  • Alvin Kamara has fumbled once this season and that is the Saints lone turnover of the season

Saints Player Injuries

  • LG Trevor Penning (toe) is listed as questionable for Sunday’s game
  • RT Taliese Fuaga (undisclosed) is listed as questionable for Sunday’s game
  • DE Chase Young (calf) is listed as questionable for Sunday’s game
  • WR Trey Palmer (hamstring) is listed as questionable for Sunday’s game
  • LG Dillon Radunz (undisclosed) is listed as questionable for Sunday’s game

Seahawks Player Injuries

  • WR Tory Horton (groin) is listed as questionable for Sunday’s game
  • RT Abraham Lucas (undisclosed) is listed as questionable for Sunday’s game
  • LB Ernest Jones IV (shoulder) is listed as questionable for Sunday’s game
  • S Julian Love (hamstring) is listed as questionable for Sunday’s game
  • CB Josh Jobe (knee) is listed as questionable for Sunday’s game
  • CB Devon Witherspoon (knee) is listed as questionable for Sunday’s game
  • S Nick Emmanwori (undisclosed) is listed as questionable for Sunday’s game
  • LB Derick Hall (undisclosed) is listed as questionable for Sunday’s game
  • DT Johnathan Hankins (back) has been declared out of Sunday’s game
  • RB Zach Charbonnet (foot) is listed as questionable for Sunday’s game

Rotoworld Bet Best Bets

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Best bets our model is projecting for this week’s game between the Saints and the Seahawks:

  • Moneyline: NBC Sports Bet is recommending a play on the New Orleans Saints on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the New Orleans Saints at +7.5.
  • Total: NBC Sports Bet is recommending a play on the over on the Game Total of 41.0.

Rotoworld has you covered with all the latest betting info & tools for NFL with player news, game predictions, player props, futures, and trends!

Follow our experts on socials to keep up with all the latest content from the staff:

● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)