A Tennessee Titans’ team (1-6) featuring an offense that is a tough watch will take the field Sunday against the Indianapolis Colts (6-1) who house one of, if not the NFL’s most efficient and effective offenses in a battle between the AFC South’s worst and first place teams.
The Colts own the NFL’s No. 2 total offense. The Titans rank No. 32 on offense. Is that the sum difference between their seasons? Quite possibly.
The statistical gap between these two teams is obviously staggering. Another telling stat is that the Colts lead the league in offensive plays of 15+ yards, while the Titans have the worst differential in the league for such plays. Tennessee’s poor play along the offensive line has no doubt contributed to this as the Titans have allowed the second-most sacks in the NFL this season.
Indianapolis’ offense ranks No. 2 overall but is the No. 1 scoring offense, averaging 33.1 points per game. The Colts’ top-ranked rushing attack is led by Jonathan Taylor, who is making a strong case for Offensive Player of the Year. Tennessee’s offense led by rookie Cam Ward averages just 235.6yds/gm and a mere 13.7pts/gm.
These teams met back in Week 3 with the Colts rolling to a 41-20 win in Nashville. Jonathan Taylor rushed for 102 yards and three touchdowns. No doubt the Titans will look to stack the box against Taylor and hope Daniel Jones fails to exploit their secondary.
Lets dive into the numbers and see what they tell us in what looks to be the most lopsided matchup of the NFL weekend.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Titans at the Colts live Sunday
- Date: Sunday, October 26, 2025
- Time: 4:25PM EST
- Site: Lucas Oil Stadium
- City: Indianapolis, IN
- Network/Streaming: CBS
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Game odds for the Titans at the Colts
The latest odds as of Wednesday courtesy of DraftKings:
- Moneyline: Tennessee Titans (+800), Indianapolis Colts (-1350)
- Spread: Colts -14
- Total: 47.5 points
This game opened at Colts -14.0 with the Game Total set at 45.0.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Tennessee at Indianapolis
- Colts Starting QB: Daniel Jones
Last Game: 10/19 at Chargers - 23-34, 288yds, 2 TDs, 0 INTs, Sacked 1 time, 5 carries for 7yds rushing
Season: 7GP, 152-214, 1790yds, 10 TDs, 3 INTs, Sacked 6 times, 29 carries for 83yds rushing - Titans Starting QB: Cam Ward
Last Game: 10/19 vs. New England - 25-34, 255yds, 1 TD, 1 INT, Sacked 5 times, 0 carries
Season: 7GP, 136-236, 1356yds, 4 TDs, 5 INTs, Sacked 30 times, 14 carries for 36yds rushing
Titans at Colts team stats, betting trends
- The Colts have won 3 straight games against AFC rivals
- The Colts have led for a league-high 55.1% of their offensive snaps
- The Titans have trailed by double digits for a league-worst 45.7% of their offensive snaps
- Indianapolis is 5-2 ATS this season
- Tennessee is 2-5 ATS this season
Titans Player Injuries
- DT Jeffery Simmons (hamstring) is questionable for Sunday’s game
- WR Calvin Ridley (hamstring) is questionable for Sunday’s game
- CB L’Jarius Sneed (quad) is doubtful for Sunday’s game
- WR Bryce Oliver (knee) is questionable for Sunday’s game
- LB Arden Key (quad) is questionable for Sunday’s game
G Blake Hance (undisclosed) is questionable for Sunday’s game
Colts Player Injuries
- WR Josh Downs (concussion) is questionable for Sunday’s game
- DE Tyquan Lewis (groin) is questionable for Sunday’s game
- DE Samson Ebukam (knee) is questionable for Sunday’s game
- CB Kenny Moore II (Achilles) is questionable for Sunday’s game
- CB Charvarius Ward (concussion) was placed on IR and has been ruled OUT of Sunday’s game
Rotoworld Best Bets
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Titans and the Colts:
- Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the Tennessee Titans at +14.
- Total: NBC Sports Bet is leaning towards a play on the under on the Game Total of 47.5.
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