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Asked whether Kittle would play in Week 1, 49ers offensive coordinator Klay Kubiak said, “We have two more practices, but Kittle looks good.” That was not as explicit as defensive coordinator Raheem Morris’ quote on Nick Bosa’s expected status just minutes earlier, but it certainly seems to confirm mounting reports that Kittle is on track to suit up for Week 1. Kubiak added at the end of his response that Kittle’s “workload will be determined,” also reinforcing earlier reports that the team was likely to monitor his snap rate closely. Fantasy managers are likely better off taking a wait-and-see approach with Kittle until he has proven to be capable of a normal workload.

During a media sessions late Monday, Morris was asked if Bosa would be able to go in Week 1 against the Rams, to which he responded, “Oh, he’s going out there. He’s going.” There’s no room left for interpretation about that quote, meaning Bosa is expected to make his return to the field after tearing his ACL in Week 3 of the 2025 season. Don’t expect a normal allotment of snaps in his first game in almost a calendar year, but the veteran pass-rusher can still make a significant impact when on the field. IDP managers will want to confirm his status on the team’s injury report Tuesday before making plans to insert him into Week 1 lineups.

It was the second straight day with the same level of participation for the second-year receiver, who could be headed for a game-day injury designation for the team’s season opener. We were kept in the dark regarding Horton’s ailment after he missed the final three weeks of camp, with a hamstring injury now labeled as the cause. Although Jake Bobo’s season-ending ACL tear all but guaranteed Horton a spot on game-day rosters, he remains unlikely to contribute meaningful counting stats playing behind Jaxon Smith-Njigba, Rashid Shaheed, and Cooper Kupp. Second-year undrafted free agent Montorie Foster Jr would be in line to serve as the team’s fourth receiver on Wednesday should Horton be unable to go.

It’s the second straight missed practice for Okada as he tends to a hamstring injury, while fellow starting safety Nick Emmanwori (ankle) is thought to be doubtful to suit up against the Patriots Wednesday, per those close to the team. The team’s final injury report of their Week 1 preparation will be released Tuesday, upon which we’ll receive final game designations. Keep a close eye on the transaction reports from Seattle to gauge the expected level of health of both players. Considering the Seahawks carried only three safeties on their initial 53-man roster, any practice squad elevations from the secondary could signal expected absences from one, or both, players.

Macdonald wouldn’t reveal what the timetable was for Charbonnet’s return, but said the fourth-year back has looked “dang good” as he continues his rehab. Charbonnet will open this season on the PUP list, meaning he’ll be forced to miss at least the first four games of the season before the team can consider activating him to play. Charbonnet suffered a torn ACL in last year’s NFC Divisional Round game against the 49ers and is less than seven full months removed from the reconstruction surgery that took place on February 20th. The timing of his injury, coupled with the surgery, led many to believe Charbonnet would miss a significant portion of the season, but this talk of an “aggressive” timetable suggests he could be back far earlier than expected.

The longest-tenured Giants player is now in search of a new home after the team opted to release the 29-year-old receiver on Monday. Slayton was reportedly at risk of not making the initial 53-man roster out of camp, but survived the initial cuts only to be released a week later. During his seven seasons with the Giants, Slayton totaled 296 receptions for 4,435 yards and 22 touchdowns while serving primarily as a field stretcher. He posted four seasons of 724 or more receiving yards and had an impressive rookie campaign when he went for 48-740-8 as a rookie fifth-rounder out of Auburn. Slayton should have no trouble finding a new home in the coming days, but it may take some time before he’s back to seeing the field in a meaningful capacity.

LaFleur said Love is “progressing” well from the high ankle sprain he suffered this preseason and said the rookie running back “was out there moving around today.” It was reported last week by NFL Network’s Mike Garafolo that he had a 50/50 chance of playing in Week 1, but it sounds like he’s trending toward being ready for the season opener. The Cardinals will release their first official injury report on Wednesday, which should give us a better sense of Love’s availability before the weekend.

Henderson traveled with the team to Seattle as it prepares for Wednesday’s game against the Seahawks, but he was unable to get on the practice field. That’s now back-to-back DNPs for Henderson, who is trending toward missing the season opener. Unless he can log a limited practice on Tuesday, it wouldn’t be surprising if Henderson was ruled out well before Wednesday’s game, paving the way for Rhamondre Stevenson to have a busy Week 1 in this rematch between last year’s Super Bowl contenders.

Mitchell missed the last six practices due to an undisclosed injury but was on the field Monday participating in drills. The Chargers don’t need to disclose any specifics regarding Mitchell’s injury until Wednesday, when they release their first official injury report of the season, but his return on Monday is an encouraging sign. Mitchell is expected to work into the mix with Omarion Hampton, who will serve as the unquestioned RB1 for the Chargers this season. Whether or not Mitchell sees enough work to be fantasy viable is to be determined, but there’s some belief he could see some work in the passing game, which could establish a decent floor for him in half and full-PPR leagues. Mitchell is an intriguing stash in fantasy leagues, but managers shouldn’t be rushing to put him in their starting lineups just yet.

This, of course, is in reference to the civil lawsuit that was filed against Nacua that alleges he bit a woman and made an “unprovoked antisemitic sentiment.” The Rams receiver avoided being placed on the commissioner’s exempt list and will travel with the team to Australia to play in their season opener against the 49ers. Nacua has been dealing with a psoas injury since August, but head coach Sean McVay said they expect him to play in Week 1. Nacua profiles as a high-end WR1 against a familiar foe in the Niners.