The Buffalo Bills (7-3) and the Houston Texans (5-5) have ruled their respective divisions the past few seasons with Josh Allen and co. winning the AFC East each of the last five seasons and C.J. Stroud and the Texans ruling the AFC South the past two years. This season was supposed to be no different, but inconsistent play and injuries have each team looking up in their respective divisions as they prepare to meet Thursday Night in Houston.
The Texans currently sit in third place in the AFC South trailing the Indianapolis Colts by three games…and that’s AFTER wins over Jacksonville and Tennessee the last two weeks. Winning the division is unlikely at this point but they sit just one game behind Trevor Lawrence and the Jacksonville Jaguars for the final wild card berth.
Of particular note this week is the status of CJ Stroud (concussion). The Houston signal caller has yet to be cleared meaning Davis Mills may well play in his third straight game and make his second consecutive start.
As noted, the Bills have controlled the AFC East since the departure of Tom Brady from New England, but the Pats are all of a sudden back and Buffalo trails them in the East by 1.5 games. An inconsistent offense has plagued the Bills. In their three losses, they have failed to eclipse 20 points and have averaged just shy of 16 points per game. That said, Josh Allen and co. have won three of their last four and expectations are they are starting to make their final push with an eye on the playoffs. This past Sunday, Allen threw three touchdown passes and scored three times himself on the ground in a 44-32 win over the Tampa Bay Buccaneers.
As is the case with Houston, there is a key injury to keep your eye on with the Bills as the week unfolds. TE Dalton Kincaid (hamstring) and his 29 receptions may well be sidelined for the matchup.
Fun Facts: The Bills have won eight consecutive Thursday Night games while the Texans have won two straight on Thursday Night as a home underdog.
Lets dive a bit deeper into the numbers and see if we can find an advantage in a specific market or two.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates from Rotoworld, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Bills and Texans live Thursday
- Date: Thursday, November 20, 2025
- Time: 8:15PM EST
- Site: NRG Stadium
- City: Houston TX
- Network/Streaming: Amazon Prime Video
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Game odds for Bills vs. Texans
The latest odds as of Monday courtesy of DraftKings:
- Moneyline: Buffalo Bills (-245), Houston Texans (+200)
- Spread: Bills -4.5
- Total: 43.5 points
This game opened at Bills -3.5 with the Game Total set at 43.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Buffalo vs. Houston
- Bills Starting QB: Josh Allen
Last Game: 11/16 vs. Tampa Bay - 19-30, 317yds, 3TDs, 2INTs, 6 carries for 40yds rushing
Season: 10GP, 204-293, 2456yds, 18TDs, 7INTs, Sacked 20 times, 65 carries for 351yds rushing - Texans Expected Starting QB: Davis Mills
Last Game: 11/16 at Tennessee - 26-41, 274yds, 1TD, 0INTs, Sacked 4 times, 2 carries for 14yds rushing
Season: 4GP, 72-120, 726yds, 3TDs, 1INT, Sacked 8 times, 10 carries for 44yds rushing
Bills vs. Texans team stats, betting trends
- The OVER has cashed just 3 times in the Texans’ 10 games this season (3-6-1)
- The OVER has cashed in half of Buffalo’s games this season (5-5)
- The Bills are 5-5 ATS this season
- The Texans are 4-6 ATS this season
Bills Player Injuries
- TE Dalton Kincaid (hamstring) is questionable for Thursday’s game
- WR Mecole Hardman (calf) is questionable for Thursday’s game
- LB Shaq Thompson (hamstring) is questionable for Thursday’s game
- DT Phidarian Mathis (shoulder) is questionable for Thursday’s game
- DE Landon Jackson (knee) was placed on IR last Tuesday and is OUT for Thursday’s game
Texans Player Injuries
- QB C.J. Stroud (concussion) is questionable for Thursday’s game
- PK Ka’imi Fairbairn (quad) is questionable for Thursday’s game
- S Jalen Pitre (concussion) is questionable for Thursday’s game
- G Ed Ingram (knee) is questionable for Thursday’s game
- LB Jamal Hill (hamstring) is questionable for Thursday’s game
- S M.J. Stewart (quad) was placed on the IR last Wednesday and is OUT for Thursday’s game
- TE Harrison Bryant (neck) was placed on IR Saturday and is OUT for Thursday’s game
Rotoworld Best Bets
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Bills and the Texans
- Moneyline: Rotoworld Bet is staying away from a play on the Moneyline.
- Spread: Rotoworld Bet is leaning towards a play ATS on the Buffalo Bills -4.5.
- Total: Rotoworld Bet is leaning towards a play on the Game Total OVER 43.5.
Rotoworld has you covered with all the latest betting info & tools for NFL with player news, game predictions, player props, futures, and trends!
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