Sunday Night Football heads to the West Coast in Week 7 when the Atlanta Falcons (3-2) visit the injury-riddled San Francisco 49ers (4-2). This is SNF’s first trip to Levi’s Stadium this season, which will host Super Bowl LX on NBC on February 8, 2026.
For a second straight season, San Francisco has been decimated by injuries. QB Brock Purdy has missed four of the first six games (including each of the last two), TE George Kittle has not played since Week 1, WR Brandon Aiyuk has not played at all, and both DE Nick Bosa and LB Fred Warner have already suffered season-ending injuries. Amidst all the bandages and surgeries, the 49ers still sit tied for first atop the NFC West.
That said, Kyle Shanahan’s troops have lost two of their last three following Sunday’s 30-19 loss at Tampa Bay. In that loss against the Buccaneers, San Francisco allowed a season-high 30 points as their struggles defensively were accentuated after losing Warner to injury in the 1st quarter.
Following their 24-14 win Monday night at home against Josh Allen and the Bills, the Falcons are 3-2 and just one game behind the aforementioned Buccaneers in the NFC South. In his first full season under center, Michael Penix Jr. has had his share of highlights and bleak moments, but Monday’s win may well serve as a launch pad for his season. No doubt it has helped to have Bijan Robinson in the backfield alongside him. The all-everything back is averaging 21 touches and just over 165 yards from scrimmage per game.
Lets take a deeper dive into this week’s matchup between the Falcons and the 49ers.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Falcons at 49ers live Sunday
- Date: Sunday, October 19, 2025
- Time: 8:20PM EST
- Site: Levi’s Stadium
- City: Santa Clara, CA
- Network/Streaming: NBC, Peacock
Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!
Game odds for the Falcons at the 49ers
The latest odds as of Tuesday courtesy of DraftKings:
- Moneyline: Atlanta Falcons (+114), San Francisco 49ers (-135)
- Spread: 49ers -2.5
- Total: 47.5 points
This game opened at 49ers with the Game Total set at 47.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Atlanta at San Francisco
- Falcons Starting QB: Michael Penix, Jr.
Last Game: 10/13 vs. Buffalo - 20-32, 250yds, 1 TD, 0 INTs, Sacked 2 times, 2 carries for 6yds
Season: 5GP, 98-157, 1168yds, 4 TDs, 3 INTs, Sacked 7 times, 15 carries for 37yds - 49ers Starting QB: Mac Jones
Last Game: 10/12 at Tampa Bay - 27-39, 347yds, 0 TDs, 2 INTs, Sacked 6 times, 5 carries for 13yds
Season: 4GP, 113-168, 1252yds, 6 TDs, 3 INTs, Sacked 11 times, 16 carries for 23yds
Falcons at 49ers team stats, betting trends
- The 49ers have won their last 10 games against teams with worse records
- The Falcons have failed to cover the spread in their last 6 road games against teams with better records
- The Under has cashed in the next game played after Monday Night Football in 4 of the last 5 such games (80%) for the Falcons
- RB Christian McCaffrey scored San Francisco’s first rushing TD of the season in the 2nd quarter this past Sunday
- McCaffrey led SF in both carries (17) and receptions (7) last Sunday and totaled 111 yards from scrimmage (54 rushing, 57 receiving)
- Christian McCaffrey has had 50+ rush yds and 50+ rec yds in five of the first six games this season.
- WR Kendrick Bourne has totaled exactly 142 receiving yards each of the last 2 weeks (career-high)
Falcons Player Injuries
- S Billy Bowman Jr. (knee) is listed as questionable for Sunday Night’s game
- DE Lacale London (triceps) is listed as questionable for Sunday Night’s game
- WR Darnell Mooney (hamstring) is listed as questionable for Sunday Night’s game
- CB Clark Phillips III (triceps) is listed as questionable for Sunday Night’s game
- LT Jake Matthews (ankle) is listed as questionable for Sunday Night’s game
49ers Player Injuries
- QB Brock Purdy (toe) is listed as questionable for Sunday Night’s game
- WR Ricky Pearsall (knee) is listed as questionable for Sunday Night’s game
- DE Yetur Gross-Matos (hamstring) is listed as questionable for Sunday Night’s game
- WR Jordan Watkins (calf) is listed as questionable for Sunday Night’s game
- WR Jauan Jennings (ribs) is listed as questionable for Sunday Night’s game
- LB Fred Warner (ankle) has been declared OUT for Sunday Night’s game
- TE George Kittle (hamstring) remains on the IR but is eligible to return and is questionable for Sunday Night’s game
Rotoworld Bet Best Bets
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Drew Dinsick (@whale_capper): Atlanta Falcons -1 (+121)
The Falcons’ defense is peaking and the Niners’ defense is waning while the injured SF squad does not look likely to get back many if any reinforcements. Good luck to the Niners defending the all-pro RB-WR duo coming to town from Atlanta.
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s Sunday Night Game between the Falcons and the 49ers:
- Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the San Francisco 49ers at -2.5.
- Total: NBC Sports Bet is recommending a play on the under on the Game Total of 47.5.
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● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)
