The Carolina Panthers (6-5) and the San Francisco 49ers (7-4) meet Monday night in Santa Clara to close out Week 12 in the NFL.
Led by Bryce Young, the Panthers have exceeded expectations to this point in the season/ Following Sunday night’s Bics’ loss, Carolina is now tied for first in the NFC South. They also are a single game behind San Francisco for the final Wild Card spot in the playoffs.
The stakes are equally high for the Niners who are looking to maintain their hold on that final playoff spot and stay within a couple games of the Rams in the NFC West. Brock Purdy (toe) returned under center last weekend for the 49ers and was an efficient 19-26 for 200 yards with three touchdowns in a 41-22 win at Arizona. It was the most points San Francisco put on the board all season.
When the schedule was released, few circled this matchup as crucial, but it is critical for each side as we enter the stretch run of the 2025 season.
Fun Fact: 49ers RB Christian McCaffrey will face his former team for the first time Monday night.
McCaffrey was drafted No. 8 overall by CAR in 2017 and spent his first 5+ seasons with the team until he was traded to SF in 2022.
Fun Fact II: Carolina has a winning record through 11 games for the first time since 2018.
Lets take dive into this week’s matchup and a handful of the numbers and see if we can fins an advantage to play.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates courtesy of Rotoworld, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Panthers vs. 49ers live Monday
- Date: Monday, November 24, 2025
- Time: 8:15PM EST
- Site: Levi’s Stadium
- City: Santa Clara, CA
- Network/Streaming: ABC
Want to check out the other games on the NFL schedule this week? We’ve got you covered at NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!
Game odds for the Panthers at the 49ers
The latest odds as of Sunday courtesy of DraftKings:
- Moneyline: Carolina Panthers (+310), San Francisco 49ers (-395)
- Spread: 49ers -7.5
- Total: 49.5 points
This game opened at 49ers -6.5 with the Game Total set at 47.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Carolina at San Francisco
- Panthers Starting QB: Bryce Young
Last Game: 11/16 at Atlanta - 31-45, 448yds, 3TDs, 0INTs, Sacked 5 times, 1 carry for -1yds rushing
Season: 10GP, 197-314, 1962yds, 14TDs, 7INTs, Sacked 19 times, 23 carries for 83yds rushing - 49ers Starting QB: Brock Purdy
Last Game: 11/16 at Arizona - 19-26, 200yds, 3TDs, 0INTs, Sacked 1 time, 1 carry for -7yds rushing
Season: 3GP, 67-99, 786yds, 7TDs, 4INTs, Sacked 3 times, 8 carries for 23yds rushing
Panthers at 49ers team stats, betting trends
- Christian McCaffrey leads the NFL with 1,439 scrimmage yds this season and is currently on pace to have 1,000+ rush yds & 1,000+ rec yds for the 2nd time in his career (2019 with CAR)
- Should he eclipse 1,000+ rush yds & 1,000+ rec yds, McCaffrey would be the first player in NFL history to have multiple seasons with 1,000+ rush yds & 1,000+ rec yds (1999 Marshall Faulk & 1985 Roger Craig are the only other players to achieve this feat even once)
- Bryce Young threw for a franchise-record 448 pass yds in the team’s OT win at Atlanta last Sunday
- The Panthers have lost 4 of their last 5 games against teams with winning records
- The 49ers have covered the spread in 4 of their last 5 home games against teams with worse records
- San Francisco is 6-5 ATS overall this season
- The OVER is 4-1 in the 49ers’ last 5 games against NFC teams
- Carolina is 7-4 ATS this season
- The OVER has cashed 7 times in the 49ers’ 11 games this season (7-3-1)
- The OVER has cashed in 6 of the Panthers’ 11 games this season (6-5)
Panthers Player Injuries
- C Cade Mays (ankle) has been ruled OUT for Monday’s game
- LB Trevin Wallace (shoulder) has been ruled OUT for Monday’s game
- LB Christian Rozeboom (hip) has been ruled OUT for Monday’s game
49ers Player Injuries
- LB Tatum Bethune (ankle) has been ruled OUT for Monday’s game
- PK Eddy Pineiro (hamstring) has been ruled OUT for Monday’s game
- LB Luke Gifford (neck) is listed as questionable for Monday’s game
- DE Robert Beal Jr. (concussion) is listed as doubtful for Monday’s game
Rotoworld Best Bets
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Panthers and the 49ers
- Moneyline: Rotoworld Bet is staying away from a play on the Moneyline.
- Spread: Rotoworld Bet is leaning towards a play ATS on the Carolina Panthers at +7.5.
- Total: Rotoworld Bet is recommending a play on the under on the Game Total of 49.5.
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