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Rams at Titans 2025 NFL Week 2 prediction: Odds, expert picks, QBs, injury update, betting trends, and stats

Its a battle of old vs. new Sunday in Nashville when Matthew Stafford and the Rams (1-0) take the field against Cam Ward and the Titans (0-1) meet Sunday.

The Super Bowl champion Stafford has thrown for 60,054 yards in his career while the rookie Ward has thrown for just 112. When looking at this matchup taking those numbers into account, Rams’ faithful are right to demand we apply the term experienced to when speaking of Stafford as opposed to old.

The veteran and the Rams outlasted Houston in Week 1, 14-9. The Rams rallied from a 9-7 halftime deficit. The difference in this defensive slugfest? The Rams were 2-3 in the Red Zone and the Texans were 0-1.

For their part, the Titans lost to the Broncos 20-12. Tennessee led 12-10 midway through the third quarter but could not hold off the Broncos down the stretch. The Titans held Denver to just 317 total yards, but they could only muster 133 yards of offense themselves.

Lets take a deeper dive into this week’s matchup between the Rams and the Titans.

NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.

Game Details and How to watch the LA Rams at the Tennessee Titans live Sunday

  • Date: Sunday, September 14, 2025
  • Time: 1:00PM EST
  • Site: Nissan Stadium
  • City: Nashville, TN
  • Network/Streaming: CBS

Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!

Game odds for the Rams at the Titans

The latest odds as of Wednesday courtesy of DraftKings:

  • Moneyline: Rams (-230), Titans (+190)
  • Spread: Rams -5.5
  • Total: 41.5 points

This game opened Rams -5.0 with the Game Total set at 45.5.

Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!

Early favorites for Offensive Rookie of the Year
Vaughn Dalzell and Jay Croucher examine the best values in the NFL Offensive Rookie of the Year race after Week 1.

Quarterback Matchup for LA Rams at Tennessee Titans

  • Rams’ Starting QB: Matthew Stafford
    Last Game: September 7 vs. Houston
    21-29 (72.4%), 245 yards, 1 TD, 0 INTs, Sacked 3 times for 21 yards, 4 carries for -2 yards
  • Titans’ Starting QB: Cam Ward
    Last Game: Septmber 7 at Denver
    12-28 (42.9%), 112 yards, 0 TDs, 0 INTs, sacked 6 times for 50 yards

Rams vs. Titans team stats, betting trends

  • Tony Pollard totaled 60 yards rushing on 18 carries and 29 yards receiving on 1 catch
  • Kyren Williams also carried the ball 18 times but gained 66 yards
  • The Titans have failed to cover in 10 of their last 12 home games
  • The Total went over in 10 of the Titans’ 17 games last season but did not cash last weekend

Rams Player Injuries

  • LG Steve Avila (ankle) is questionable for Sunday’s game
  • RG Kevin Dotson (ankle) is questionable for Sunday’s game
  • TE Colby Parkinson (shoulder) is questionable for Sunday’s game

Titans Player Injuries

  • RT JC Latham (hip) is questionable for Sunday’s game
  • S Kevin Winston Jr. (undisclosed) is questionable for Sunday’s game

Rotoworld Bet Best Bets

Drew Dinsick (@whale_capper): Game Total UNDER 41.5 (-108)

The pressure statistics allowed by the Titans in Week 1 were astonishing, Cam Ward faced pressure on 50% of his dropbacks and the test gets no easier in his second start against a young and rising pass rush group from SoCal. Questions swirling about the health of the Rams OL makes this likely another conservative game plan from McVay as the Rams look for a clean win on the strength of their smothering defense.

Trysta Krick (@Trysta_Krick): Tennessee Titans’ Team Total UNDER 17.5 (-115)

This one has all the makings of a defensive grind. The Rams defense just held the Houston Texans to nine points — and it wasn’t fluky. Houston couldn’t get anything going at any level. The passing game stalled, third-down conversions were a mess, and the Rams’ defensive front lived in the backfield. Three different Rams defenders sacked C.J. Stroud for big losses, setting the tone all afternoon.

Now the question becomes: what happens when that same defense lines up against Cam Ward and Tennessee? We already saw what Ward looked like against a top-tier defense in Denver — it was “night night.” If the Rams can generate similar pressure, it’s hard to imagine the Titans’ offense finding much success.

The angle I like most here is Tennessee’s team total under. This feels like a spot where points are going to be nearly impossible to come by. On top of that, with the Rams’ own offense still sputtering, I also lean to the full game under 41.5.

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Best bets our model is projecting for this week’s game between the Rams and the Titans:

  • Moneyline: NBC Sports Bet is recommending a play on the Tennessee Titans on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the Tennessee Titans at +5.5.
  • Total: NBC Sports Bet is staying away from a play on the Game Total of 42.0.

Rotoworld has you covered with all the latest betting info & tools for NFL with player news, game predictions, player props, futures, and trends!

Follow our experts on socials to keep up with all the latest content from the staff:

● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)