Six-game PED suspension overturned for Arden Key

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Arden Key

TEN Linebacker #49
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Titans EDGE Arden Key had his six-game suspension for performance-enhancing drugs overturned on Saturday.

The ruling is a boon for the Titans’ defensive front that enters 2024 with somewhat shallow depth in the EDGE department. Key profiles as a capable No. 2 EDGE, ranking 33rd in pass-rush win rate (12.6 percent) among 64 NFL EDGE players with at least 295 pass-rushing snaps last year.

Source: The Athletic

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Mike Evans

SF Wide Receiver #5
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Mike Evans (ribs) is not on the final injury report and will play in Week 5 against the Seahawks.

The 49ers’ star wide receiver is good to go for his team’s Week 5 game against a divisional rival. A hard hit to the midsection could change his day, but Evans is extremely tough and should be expected to handle his normal workload. He is a weekly WR2, operating as San Francisco’s passing game focal point.
- Nic Bodiford

Injury

Source: Matt Barrows

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Pickens emerges from Lamb's fantasy shadow

Kyle Dvorchak unpacks George Pickens' elite performance on Thursday Night Football against the Tampa Bay Buccaneers, and what that means for his fantasy football outlook going forward.

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Nick Bosa

SF Defensive Lineman #97
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49ers ruled out Nick Bosa (knee/calf) for Week 5 against the Seahawks.

The 49ers will be without Bosa, FB Kyle Juszczyk (knee), DL James Thompson Jr. (ankle) and S Marques Sigle (ankle) for this divisional showdown, making life a little easier on their opponent.
- Nic Bodiford

Injury

Source: Matt Barrows
Kyle Juszczyk

James Thompson Jr.

Marques Sigle
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Mykel Williams

SF Defensive Lineman #98
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49ers DL Mykel Williams (knee) is questionable for Week 5 against the Seahawks

Williams is officially listed as questionable, though he is expected to take the field for the first time since tearing his ACL in Week 9, during this 2025 rookie season. His return could not have come soon enough. The 49ers’ defensive line has been hit hard by injuries this year. The 49ers correspondingly released DL Ogbo Okoronkwo to make room on the active roster.
- Nic Bodiford

Injury

Source: Nick Wagoner
Ogbo Okoronkwo
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Lil'Jordan Humphrey

DEN Wide Receiver
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Broncos signed WR Lil’Jordan Humphrey off their own practice squad.

Every year it somehow comes to this. Humphrey will replace Pat Bryant (IR/ankle) on the 53-man roster. We expect Troy Franklin and Marvin Mims will have more opportunities than Humphrey to actually catch the ball.
- Rivers McCown

Transaction

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Leonard Williams

SEA Defensive Tackle #99
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Seahawks DT Leonard Williams (ankle)is not on the final injury report and will play in Week 5 against the 49ers.

The Seahawks will have their stud interior defender on hand against the division-rival 49ers. They will be without backup CB Julian Neal (hamstring), who suffered an injury in practice.
- Nic Bodiford

Injury

Source: Gregg Bell

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Walter Nolen

ARI Defensive Lineman #97
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Cardinals DT Walter Nolen (calf) is questionable for Arizona’s Week 5 game against the Lions.

Nolen was limited in back-to-back practices after popping up with the calf listing on Thursday. He’s played 319 snaps in 21 career opportunities so far.
- Rivers McCown

Injury

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George Holani

SEA Running Back #36
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Seahawks RB George Holani (ribs/knee) is questionable to play in Week 5 against the 49ers.

Holani was nursing a ribs injury on Wednesday and Thursday, but he is now listed with a knee injury as well. This is concerning. He clearly picked up a new injury during the practice week. Velus Jones is the current RB3. Jones is not viable as a FLEX starter if Holani sits, but Emanuel Wilson should take on an RB2-worthy workload regardless.
- Nic Bodiford

Injury

Source: John Boyle
Emanuel Wilson

Velus Jones Jr.
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Jeremiyah Love

ARI Running Back #4
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Jeremiyah Love (ankle) is not on Arizona’s final Week 5 injury report.

Cardinals coach Mike LaFleur said “It’s a maintenance thing with ankles, you guys see the way he cuts...I don’t know what he’s totally feeling, only he knows...but he’s doing good.” Great, not cryptic at all, Mike. Love is a reasonable low-end RB2 if his ankles decide he wants to play his full allotment of the 50/50 split against the Lions in Week 5.
- Rivers McCown

Injury

Source: Bo Brack

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Trevor Penning

LAC Offensive Lineman #75
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Trevor Penning (concussion) won’t play in Los Angeles’ Week 5 game against the Broncos.

We’re assuming the Chargers are going to sign some offensive linemen to the 53-man roster, but as things currently stand it looks like four rookies will start next to Cole Strange. And we don’t even know which four, if you really want to see how deep this despair goes.
- Rivers McCown

Injury

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Trey Lance

LAC Quarterback #5
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Trey Lance (groin) is doubtful for Los Angeles’ Week 5 game against the Broncos.

The rarely-seen doubtful tag. Only the Chargers could discover a way for their backup quarterback to get it. DJ Uiagalelei could backup Justin Herbert this week.
- Rivers McCown

Injury
DJ Uiagalelei
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Rotoworld

Arden Key

Titans EDGE Arden Key had his six-game suspension for performance-enhancing drugs overturned on Saturday.

Mike Evans

Mike Evans (ribs) is not on the final injury report and will play in Week 5 against the Seahawks.

Nick Bosa

49ers ruled out Nick Bosa (knee/calf) for Week 5 against the Seahawks.

Mykel Williams

49ers DL Mykel Williams (knee) is questionable for Week 5 against the Seahawks

Lil'Jordan Humphrey

Broncos signed WR Lil’Jordan Humphrey off their own practice squad.

Leonard Williams

Seahawks DT Leonard Williams (ankle)is not on the final injury report and will play in Week 5 against the 49ers.

Walter Nolen

Cardinals DT Walter Nolen (calf) is questionable for Arizona’s Week 5 game against the Lions.

George Holani

Seahawks RB George Holani (ribs/knee) is questionable to play in Week 5 against the 49ers.

Jeremiyah Love

Jeremiyah Love (ankle) is not on Arizona’s final Week 5 injury report.

Trevor Penning

Trevor Penning (concussion) won’t play in Los Angeles’ Week 5 game against the Broncos.

Trey Lance

Trey Lance (groin) is doubtful for Los Angeles’ Week 5 game against the Broncos.