Following last week’s monster comeback on the road at AFC East-leading New England, Josh Allen and the Buffalo Bills (10-4) are in Cleveland to take on Shedeur Sanders and the Browns (3-11).
The Bills trailed last Sunday 21-0 to the Patriots before storming back for a 35-31 win. No team has more comebacks from a double-digit deficit this season than Buffalo who has done so three times. Sean McDermott’s crew is now within one game of first place New England.
As a result of that comeback the Bills are one win away from a sixth straight season of 11+wins which would tie the Dallas Cowboys (1976-1981) for the fourth longest streak in NFL history (2010-19 New England – 10, 2018-24 Kansas City – 7, 2003-09 Indianapolis – 7). ***All of those teams other than Buffalo have won at least 1 Super Bowl during their extended stretch of superior results.
More importantly, Buffalo is seeking its seventh straight playoff appearances (longest active streak in NFL). Allen and co. clinches a playoff berth with a win and a loss/tie by either Indianapolis or Houston.
For the Browns, the highlight of their season is the play of All-Pro DE Myles Garrett. The future Hall of Famer has 21.5 sacks this season, 1.5 shy of setting the single season record established by Michael Strahan in 2001 and equaled by T.J. Watt in 2021. Only two players, however, have sacked Josh Allen 1.5+ times this season: Houston’s Will Anderson (2.5) and Danielle Hunter (2.0).
Lets take a deeper dive into this week’s matchup between the Bills and the Browns.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Bills vs. Browns live Sunday
- Date: Sunday, December 21, 2025
- Time: 1:00PM EST
- Site: Huntington Bank Field
- City: Cleveland, OH
- Network/Streaming: CBS
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Game Odds: Bills at Browns
The latest odds as of Thursday courtesy of DraftKings:
- Moneyline: Buffalo Bills (-675), Cleveland Browns (+490)
- Spread: Bills -10.5
- Total: 41.5 points
This game opened at Bills -8.5 with the Game Total set at 42.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Buffalo at Cleveland
- Bills Starting QB: Josh Allen
Last Game: 12/14 at New England - 19-28, 193yds, 3TDs, 0INTs, Sacked 2 times, 11 carries for 48yds rushing
Season: 14GP, 284-406, 3276yds, 25TDs, 10INTs, Sacked 33 times, 98 carries for 535yds rushing
- Browns Starting QB: Shedeur Sanders
Last Game: 12/14 at Chicago - 18-35, 177yds, 0TDs, 3INTs, Sacked 5 times, 2 carries for 24yds rushing
Season: 5GP, 72-138, 946yds, 5TDs, 6INTs, Sacked 13 times, 10 carries for 74yds rushing
Bills at Browns: Team Stats and Betting Trends
- James Cook ranks 2nd in rushing yds (1,415) in the NFL this season behind Jonathan Taylor (1,443) of the Colts
- Out of 44 QBs with at least 100+ pass attempts this season, Shedeur Sanders ranks last in completion pct (52.2%) and passer rating (68.1)
- Josh Allen has 299 career total TDs in 125 reg. season games
- With 1 more TD, he will pass Aaron Rodgers for the fewest games needed (134) to reach 300 total TD in NFL history
- With that next TD, Allen would also be the first with 300 career TD before turning 30 in NFL history
- The OVER has cashed in 7 games for both Cleveland (7-7) and Buffalo (7-7)
- The Bills are 7-7 ATS this season
- The Browns are 5-9 ATS this season
Bills Player Injuries
- TE Dalton Kincaid (knee) is listed as questionable for Sunday’s game
- LT Dion Dawkins (illness) is listed as questionable for Sunday’s game
- WR Brandin Cooks (undisclosed) is listed as questionable for Sunday’s game
- LB Terrel Bernard (elbow) is listed as questionable for Sunday’s game
- CB Christian Benford (toe) is listed as questionable for Sunday’s game
- PK Matt Prater has been declared OUT of Sunday’s game
- DT Jordan Phillips has been declared OUT of Sunday’s game
Browns Player Injuries
- RB Dylan Sampson (calf) is listed as questionable for Sunday’s game
- TE David Njoku (knee) is listed as questionable for Sunday’s game
- LG Joel Bitonio (knee) is listed as questionable for Sunday’s game
- RG Wyatt Teller (undisclosed) is listed as questionable for Sunday’s game
- RT Jack Conklin undisclosed) is listed as questionable for Sunday’s game
- OG Teven Jenkins (shoulder) is listed as questionable for Sunday’s game
- OG Zak Zinter (undisclosed) is listed as questionable for Sunday’s game
- DT Mason Graham (ribs) is listed as questionable for Sunday’s game
- DT Mike Hall Jr. (undisclosed) is listed as questionable for Sunday’s game
- DT Sam Kamara (elbow) is listed as questionable for Sunday’s game
- LB Carson Schwesinger (ankle) is listed as questionable for Sunday’s game
- CB Denzel Ward (calf) is listed as questionable for Sunday’s game
- S Grant Delpit (groin) is listed as questionable for Sunday’s game
Rotoworld Best Bets
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Bills and the Browns
- Moneyline: Rotoworld Bet is staying away from a play on the Moneyline.
- Spread: Rotoworld Bet is recommending a play ATS on the Buffalo Bills -10.
- Total: Rotoworld Bet is leaning towards a play on the UNDER on the Game Total of 42.5.
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