Skip navigation
Favorites
Sign up to follow your favorites on all your devices.
Sign up
Odds by

Bills vs. Steelers prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats

The Steel City is the backdrop for Sunday’s game featuring Josh Allen and the Buffalo Bills taking on Aaron Rodgers and the Pittsburgh Steelers.

The matchup is an interesting one for a multitude of reasons. The Steelers are now tied for first with Baltimore and could be 1/2 game behind them before they finish their dessert on Thanksgiving. With it looking more and more likely that the winner of the AFC North will be the only team in the division to make the playoffs, each of Pittsburgh’s remaining games are now critical.

Winners of five straight AFC East crowns, the Buffalo Bills sit two games behind the Patriots. It appears their only route to the postseason is as a Wild Card. They currently reside in 7th but just a game behind them sit Patrick Mahomes and C.J. Stroud. Few expect the Chiefs to miss the playoffs and after a horrendous start, the Texans are coming on strong.

Buffalo lost to those Texans last week in Houston, 23-19, and the Steelers were losers at home to the Bears, 31-28.

Lets take a deeper dive into this week’s matchup between the Bills and the Steelers.

NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates courtesy of Rotoworld, and of course our predictions and best bets for the game from our staff of experts.

Game Details and How to watch the Bills vs. Steelers live Sunday

  • Date: Sunday, November 30, 2025
  • Time: 4:25PM EST
  • Site: Acrisure Stadium
  • City: Pittsburgh, PA
  • Network/Streaming: CBS

Want to check out the other games on the NFL schedule this week? We’ve got you covered at NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!

Game odds for the Bills at the Steelers

The latest odds as of Tuesday courtesy of DraftKings:

  • Moneyline: Buffalo Bills (-185), Pittsburgh Steelers (+154)
  • Spread: Bills -3.5
  • Total: 47.5 points

This game opened at Bills -4 with the Game Total set at 47.5.

Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!

Analyzing odds to make playoffs in 'wide open' AFC
Chris Simms and Connor Rogers look at the updated odds to make the playoffs in the AFC, looking at the Bills, Chargers, Texans and Chiefs.

Quarterback Matchup for Buffalo at Pittsburgh

  • Bills Starting QB: Josh Allen
    Last Game: 11/20 at Houston - 24-34, 253yds, 0TDs, 2INTs, Sacked 8 times, 5 carries for 20yds rushing
    Season: 11GP, 228-327, 2709yds, 18TDs, 9INTs, Sacked 28 times, 70 carries for 371yds rushing
  • Steelers Starting QB: Aaron Rodgers
    Last Game: 11/16 vs. Cincinnati - 9-15, 116yds, 1TD, 0INTs, Sacked 1 time, 1 carry for 8yds rushing
    Season: 10GP, 192-289, 1969yds, 19TDs, 7INTs, Sacked 19 times, 14 carries for 26yds rushing

Bills at Steelers team stats, betting trends

  • Sean McDermott is 3-1 in his career against Mike Tomlin
  • The Steelers have lost 4 of their last 5 games against teams with winning records
  • The Steelers has failed to cover the spread in 7 of their last 9 games against teams with winning records
  • The UNDER is 4-1 in the Bills’ last 5 games against AFC opponents
  • The Steelers and the Bills are each 5-6 ATS this season
  • The OVER has cashed in 5 of the Bills’ 11 games this season (5-6)
  • The Bills have turned the ball over three times in three straight games, for the first time since 1986

Bills Player Injuries

  • WR Curtis Samuel (elbow) is listed as questionable for Sunday’s game
  • TE Dalton Kincaid (hamstring) is listed as questionable for Sunday’s game
  • DT Phidarian Mathis (shoulder) is listed as questionable for Sunday’s game
  • RT Spencer Brown (shoulder) is listed as doubtful for Sunday’s game
  • CB Maxwell Hairston (concussion) is listed as questionable for Sunday’s game
  • RT Tylan Gable (concussion) has been designated to return from the IR but has not yet been activated

Steelers Player Injuries

  • QB Aaron Rodgers (wrist) is listed as questionable for Sunday’s game
  • WR DK Metcalf (ankle) is listed as questionable for Sunday’s game
  • CB Joey Porter Jr. (hip) is listed as questionable for Sunday’s game
  • LB Alex Highsmith (undisclosed) is listed as questionable for Sunday’s game
  • OT Broderick Jones (neck) has been ruled OUT for Sunday’s game
  • DT Derrick Harmon (knee) has been declared OUT for Sunday’s game

Rotoworld Best Bets

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Best bets our model is projecting for this week’s game between the Bills and the Steelers

  • Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the Buffalo Bills at -3.5.
  • Total: NBC Sports Bet is recommending a play on the OVER on the Game Total of 47.5.

Rotoworld has you covered with all the latest betting info & tools for NFL with player news, game predictions, player props, futures, and trends!

Follow our experts on socials to keep up with all the latest content from the staff:

● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)