Undefeated Denver (1-0) travels to Indianapolis for an encounter this Sunday against the Colts (1-0).
Daniel Jones was near-perfect in his debut with the Colts completing 22 of 29 passes (75.9%) for 272 yards including one touchdown and two more on the ground in a 33-8 smackdown of the Miami Dolphins. The win snapped an 11-game losing streak on Opening Day for Indy.
The Denver Broncos escaped Week 1 with a 20-12 win over Cam Ward and the Tennessee Titans. Bo Nix threw for only 166 yards with one touchdown and two interceptions. The sophomore also lost a fumble in what had to be seen as a disappointing performance following an impressive rookie season. That said, Denver’s defense was suffocating allowing the Titans’ just 133 yards.
Can the Colts maintain their offensive production? Can Bo Nix find the form he displayed late last season or is he at the beginning of a sophomore slump?
Lets take a deeper dive into this week’s matchup between the Broncos and the Colts.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Broncos at the Colts live Sunday
- Date: Sunday, September 14, 2025
- Time: 4:05PM EST
- Site: Lucas Oil Stadium
- City: Indianapolis, IN
- Network/Streaming: CBS
Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!
Game odds for the Broncos at the Colts
The latest odds as of Thursday courtesy of DraftKings:
- Moneyline: Denver Broncos (-130), Indianapolis Colts (+110)
- Spread: Broncos -1.5
- Total: 42.5 points
This game opened Broncos -3.5 with the Game Total set at 44.5.
Read More: Vaughn Dalzell’s Best Bets for Week 2 in the NFL
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Denver at Indianapolis
- Denver Starting QB: Bo Nix
Last Game: September 7 vs. Tennessee
25-40 (62.5%), 176 yards, 1 TD, 2 INTs, Sacked 1 time for a 10-yard loss, 8 carries for 18 yards - Indianapolis Starting QB: Daniel Jones
Last Game: September 7 vs. Miami
22-29 (75.9%), 272 yards, 1 TD, 0 INTs, Sacked 1 time for a 10-yard loss, 7 rushes for 26 yards with 2 TDs
Denver Broncos at Indianapolis Colts team stats, betting trends
- AFC West teams have won 4 of their last 5 games against AFC South teams
- The Broncos have failed to cover in their last 3 on the road
- 6 of the Colts’ last 8 games (75%) have gone OVER the Total
Broncos Player Injuries
- TE Evan Engram (calf) is listed as questionable for Sunday’s game
- DE John Franklin-Myers (knee) is listed as questionable for Sunday’s game
- LB Dre Greenlaw (quad) is listed as questionable for Sunday’s game
- FB Michael Burton was placed on IR earlier this week and is OUT of Sunday’s game
- TE Nate Adkins (undisclosed) is listed as questionable for Sunday’s game
- DT Malcolm Roach (calf) was placed on IR last weekend
Colts Player Injuries
- DE Laiatu Latu (undisclosed) is listed as questionable for Sunday’s game
- CB Charvarius Ward (concussion) is listed as questionable for Sunday’s game
- CB Jaylon Jones (undisclosed) is listed as questionable for Sunday’s game
Rotoworld Bet Best Bets
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Drew Dinsick (@whale_capper): Denver -1.5 (-109)
Bo Nix had one of the least convincing winning performances on Sunday but thanks to a suffocating defensive effort the Broncos avoided catastrophe. The Colts on the other hand surprised to the good but in my opinion that could be easily chalked up to effort on the part of the Fins. The lookahead here was -3.5 so this adjustment seems way too high, if not wrong altogether.
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Broncos and the Colts:
- Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the Indianapolis Colts at +2.5.
- Total: NBC Sports Bet is recommending a play on the over on the Game Total of 42.0.
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Follow our experts on socials to keep up with all the latest content from the staff:
● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)
