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Dolphins at Panthers prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats

Sunday in Charlotte the Carolina Panthers (1-3) host the Miami Dolphins (1-3).

We have been here before but is this Bryce Young’s last opportunity to remain as QB1 for the Panthers? Does a Miami loss spell the immediate end for Mike McDaniel?

McDaniel and the Dolphins got into the win column for the first time this season this past Monday night. Tua Tagovailoa and co. outlasted the Jets, 27-21. Miami took advantage of a porous Jets’ defense and mistake-prone offense to garner their first win of the season. Leading receiver Tyreek Hill, however, was lost for the season to a knee injury.

The Panthers were embarrassed by New England, 42-13. Bryce Young directed a scoring drive for Carolina on their first possession but failed to put any points on the board the rest of the game ultimately giving way to Andy Dalton who did lead Carolina to a touchdown late in the fourth quarter.

Lets take a deeper dive into this Week 5 matchup between the Dolphins and the Panthers.

NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.

Game Details and How to watch the Dolphins at Panthers live Sunday

  • Date: Sunday, October 5, 2025
  • Time: 1:00PM EST
  • Site: Bank of America Stadium
  • City: Charlotte, NC
  • Network/Streaming: FOX

Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!

Game odds for the Dolphins at the Panthers

The latest odds as of Thursday courtesy of DraftKings:

  • Moneyline: Dolphins (-120), Panthers (+100)
  • Spread: Dolphins -1.5
  • Total: 45.5 points

This game opened at Panthers -1.0 with the Game Total set at 45.5.

Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!

Quarterback Matchup for Miami at Carolina

  • Dolphins Expected Starting QB: Tua Tagovailoa
    Last Game: 9/29 vs. NY Jets - 17-25, 177yds, 2 TDs, 0 INTs, 0 sacks, 3 carries for 6yds
    Season: 4GP, 79-114, 752yds, 7 TDs, 4 INTs, Sacked 8 times, 6 carries for 23yds
  • Panthers Expected Starting QB: Bryce Young
    Last Game: 9/28 at New England - 18-30, 150yds, 1 TD, 0 INTs, Sacked 1 time, 1 carry for 3yds
    Season: 4GP, 87-144, 753yds, 5 TDs, 3 INTs, Sacked 6 times, 10 carries for 53yds

Dolphins at Panthers team stats, betting trends

  • The Dolphins have won 3 straight following an appearance on Monday Night Football
  • The Dolphins and Panthers are each 2-2 ATS this season
  • Game Totals involving Miami are 3-1 to the OVER this season
  • Game Totals involving Carolina are 2-2 to the OVER this season
  • The Under is 8-2 in the Dolphins’ last 10 road games

Dolphins Player Injuries

  • TE Darren Waller (hip) is questionable for Sunday’s game
  • WR Cedric Wilson (undisclosed) is questionable for Sunday’s game
  • CB Storm Duck (ankle) is questionable for Sunday’s game
  • WR Tyreek Hill (knee) has been placed on IR and is OUT for the season
  • CB Ethan Bonner (hamstring) is questionable for Sunday’s game

Panthers Player Injuries

  • DT Tershawn Wharton (toe) is questionable for Sunday’s game
  • CB Chau Smith-Wade chest) is questionable for Sunday’s game
  • RB Chuba Hubbard (calf) is questionable for Sunday’s game
  • TE Ja’Tavion Sanders (ankle) is questionable for Sunday’s game
  • LB D.J. Wonnum (undisclosed) is questionable for Sunday’s game

Rotoworld Bet Best Bets

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Take the Dolphins to cover against the Panthers
The Fantasy Football Happy Hour crew shares their early best bets for NFL Week 5, including taking the Miami Dolphins to cover against the Carolina Panthers.

Drew Dinsick (@whale_capper): Carolina Panthers -1½ (+102)

Counting on a better performance by Bryce Young and company at home facing an inferior defense on a short week. Add to the mix that the top playmaker in Hill is done for the Fins and this should be Panthers small favorite in my opinion.

***

Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Best bets our model is projecting for this week’s game between the Dolphins and the Panthers:

  • Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the Miami Dolphins at +1.5.
  • Total: NBC Sports Bet is recommending a play on the over on the Game Total of 44.0.

Rotoworld has you covered with all the latest betting info & tools for NFL with player news, game predictions, player props, futures, and trends!

Follow our experts on socials to keep up with all the latest content from the staff:

● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)