Week 4 of the NFL season kicks off Thursday night in the desert. Its an NFC West showdown between the Seattle Seahawks (2-1) and the Arizona Cardinals (2-1). Playing in maybe the most competitive division in football, each side needs a win to keep pace with the Rams and 49ers.
Sam Darnold and the Seahawks are looking to build on last week’s 44-13 thumping of the Saints. This game was over well before halftime as Seattle led 21-0 after the first 15 minutes. For the game, Seattle made five trips inside the Red Zone and scored on four of them.
Meanwhile, the Cardinals are coming off a disappointing, 16-15 loss on the road at the aforementioned 49ers. Eddie Pineiro’s 35-yard field goal as time expired was the difference.
Lets dive into the matchup and perhaps find a couple of sweats along the way.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Seattle Seahawks and the Arizona Cardinals live Thursday
- Date: Thursday, September 25, 2025
- Time: 8:15PM EST
- Site: State Farm Stadium
- City: Glendale, AZ
- Network/Streaming: Amazon Prime Video
Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!
Game odds for the Seahawks vs the Cardinals
The latest odds as of Tuesday courtesy of DraftKings:
- Moneyline: Seattle Seahawks (-105), Arizona Cardinals (-115)
- Spread: Cardinals -1.5 (-102)
- Total: 43.5 points
This game opened at Cardinals -2.5 with the Game Total set at 44.0.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Seattle vs. Arizona
- Seahawks Starting QB: Sam Darnold
Last Game: 9/21 vs. New Orleans – 14-18 (77.8%), 218yds, 2 TDs, 0 INTs, Was not Sacked
Season: 3GP, 52-74 (70.3%), 663yds, 4 TDs, 2 INTs, Sacked 3 times, 2 carried for 14yds - Cardinals Starting QB: Kyler Murray
Last Game: 9/21 at San Francisco – 22-35 (62.9%), 159yds, 1 TD, 0 INTs, Sacked 1 time, 6 carries for 37yds
Season: 60-89 (67.4%), 542yds, 4 TDs, 1 INT, Sacked 7 times, 20 carries for 107yds
Seattle Seahawks at Arizona Cardinals team stats, betting trends
- The Seahawks have won four straight NFC West matchups
- The Cardinals have covered the Spread in five of their last six home games
- The Cardinals’ last three home games have gone OVER the Total
Seahawks Player Injuries
- FB Robbie Ouzts (ankle) is questionable for Thursday’s game
- C Jalen Sundell (undisclosed) is questionable for Thursday’s game
- DE Leonard Williams (elbow) is questionable for Thursday’s game
- LB Boye Mafe (undisclosed) is questionable for Thursday’s game
- FS Jalen Love (undisclosed) is questionable for Thursday’s game
- S Nick Emmanwori (undisclosed) is questionable for Thursday’s game
- TE Elijah Arroyo (groin) is questionable for Thursday’s game
- G Josh Jones (undisclosed) is questionable for Thursday’s game
Cardinals Player Injuries
- WR Zay Jones (concussion) is questionable for Thursday’s game
- LT Paris Johnson Jr. (undisclosed) is questionable for Thursday’s game
- LG Evan Brown (undisclosed) is questionable for Thursday’s game
- LB Akeem Davis-Gaither (elbow) is questionable for Thursday’s game
- CB Will Johnson (undisclosed) is questionable for Thursday’s game
- DT Walter Nolen III has been declared out of Thursday’s game
- G Will Hernandez (undisclosed) is questionable for Thursday’s game
- RB James Conner (foot) has undergone season-ending surgery and is thus out for Thursday’s game
Rotoworld Bet Best Bets
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Seahawks and the Cardinals:
- Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the Seattle Seahawks at +1.5.
- Total: NBC Sports Bet is recommending a play on the over on the Game Total of 43.5.
Enjoy the game!
Rotoworld has you covered with all the latest betting info & tools for NFL with player news, game predictions, player props, futures, and trends!
Follow our experts on socials to keep up with all the latest content from the staff:
● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)
