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The team pulled the plug on Flowers’ potential to play in Week 2 after the veteran receiver departed the team’s Week 1 win with a hamstring injury. No word yet on how long the injury is expected to sideline Flowers, who appears to have a good shot at suiting up when the team faces off against the Cowboys on the road in Week 3. Tight end Mark Andrews could see a slight uptick in volume in the interim.

The Texans received relatively good news from initial testing, which revealed a Grade 1 hamstring injury. Even so, word around the team is that they are preparing to be without their star receiver for two games, which makes sense considering his lengthy soft tissue injury history. Fantasy managers will want to make alternate plans after losing one of their top selections off the board.

Nacua did not practice for the second consecutive day Saturday, prompting the questionable designation for Monday Night Football. The issue is now being called a groin ailment and is reportedly unrelated to the psoas injury he dealt with during the offseason. Fantasy managers will want to start making alternate plans for their first-round pick considering the Rams don’t play until the final game of the week. Jordan Whittington is listed as doubtful with a quad injury.

Pittman was unable to get on the practice field this week and will now miss Week 2 as a result of a foot injury. DK Metcalf enters the WR2 discussion in a difficult matchup on paper after ranking in the top five in expected fantasy points in Week 1, for an offense near the top of the league in pass rate over expectation in their first game. Third-year receiver Roman Wilson and rookie Germie Bernard see an uptick in value, although both are difficult starts outside the deepest of leagues. Tight end pat Freiermuth can be started as a back-end TE1 in a pinch.

The news was first reported by NFL Insider Ian Rapoport. Cooper is going on injured reserve for an ankle sprain. He’ll be sidelined for at least four games with a designation to return. Rapoport mentions that Cooper should be back “shortly.” Cooper could still make an impact in the second half of his rookie season, but he isn’t worth holding in most fantasy formats at this point.

Appearing on the Rich Eisen Show Friday, Breer was quick to point out the Lions’ defensive struggles. Detroit has allowed 917 yards and 71 points in two games. Breer noted that while the Lions are dealing with injuries in the secondary, that doesn’t excuse their problems in the running game. Detroit has allowed 294 rushing yards, 4.8 yards per carry and four rushing touchdowns this year. While it’s still early in the season, Breer says the Lions defensive performance isn’t a “one-off” and that it’s been “messy” for a while. It was a stark contrast from NFL Insider Ian Rapoport’s take on the Pat McAfee show earlier this week where he said, “My guess is the Lions are going to be fine.” Lions HC Dan Campbell has pulled the plug on his offensive coordinator midseason twice in five years, but has afforded his defensive coordinators a longer leash. Sheppard was promoted from linebackers coach to defensive coordinator after Aaron Glenn was hired by the Jets prior to the 2025 season.

Thomas missed a little time in Week 1 after landing on his injured shoulder, but was able to return. The Jaguars’ X-receiver could face Broncos CB Pat Surtain on the perimeter this week, but he should get a few chances to make big plays downfield. He remains a FLEX starter in Week 2.

This could be related to the groin and psoas issues Nacua dealt with in August and earlier this month. The Rams’ star wide receiver has an extra day to get this figured out, but it is a tad concerning. For now, make backup plans. It is possible that Nacua is unable to play in Week 2 against the Giants on Monday night. Nacua’s direct backup, WR Jordan Whittington (quad), also missed practice on Friday.

Earlier today, NFL Network’s Ian Rapoport reported that Donald “hopes” to play on Monday night. A few hours later, Rams coach Sean McVay said he hopes Donald will play this week, but that they need to listen to how Donald is feeling after going through team drills. Donald is evidently feeling good following Friday’s practice and should apparently be expected to face the Giants.

McBride is good to go for the Cardinals’ matchup against the Seahawks and can be treated as a shoo-in TE1, per usual. The Seahawks are without S Ty Okada (hamstring), theoretically making life a little easier for McBride. Fellow S Nick Emmanwori (hip/ankle) is questionable.