CMC (tightness) time off was ‘kind of’ planned

McCaffrey and Williams were listed as DNP simply for rest, while Bosa had a rest/knee designation and Greenlaw had a rest/Achilles designation. This is notable as the 49ers have several key veterans who have dealt with injuries throughout their career and practice reps will be managed for these players, especially coming off a Week 1 in Australia. McCaffrey reportedly dealt with cramps in the 49ers’ Week 1 win over the Rams; though he is not injured, his experiences with Achilles tendinitis will certainly lend to rest days throughout the season. We expect the 49ers to continue to rest veterans in practice throughout the season in an effort to remain healthy.

McCaffrey’s usage was a bit underwhelming in the first half of Thursday’s win. The 30-year-old running back played on 20 offensive snaps to Kaelon Black’s, while Black’s seven rush attempts more than doubled the three carries we saw from CMC, who also saw six first-half targets. McCaffrey’s second-half usage saw a slight uptick, but it’s possible some of what we saw as it pertains to last night’s split was related to this cramping issue. McCaffrey was undoubtedly the more efficient of the two Niners backs in last night’s win, but Black was solid in his debut, rushing 14 times for 65 yards. McCaffrey should be positioned for a big Week 2 game next week against the Dolphins.

The man they call CMC was not a big part of the first-half attack, but saw plenty more touches over the final two quarters to turn what was looking like an ugly fantasy debut into a decent — although far from spectacular — outing for the 30-year-old veteran. It’s worth noting that Kaelon Black received 14 carries in the contest for 68 yards, and it’s likely that Black is going to be involved going forward in at least a somewhat similar capacity. McCaffrey should still get plenty of touches going forward, and should have a good day against the Dolphins in Week 2.

While most of us were asleep on Sunday night, the 49ers were already conducting a Monday afternoon practice in Australia. According to NBC Sports’ Matt Maiocco, McCaffrey was not seen taking part in drills during the early portion of practice. It’s possible this is by design as the Niners prepare for their season opener on Thursday against the Rams, so we won’t read too much into this just yet. McCaffrey missed some time during training camp due to “tightness,” but seemingly downplayed any idea of an injury when he later said the time off during camp was “the plan from the jump.” This is something to keep an eye on in the coming days, but for now, we’ll assume McCaffrey will be good to go for the season opener. According to Maiocco, DE Nick Bosa was also not spotted during the early portion of practice on Monday.

On the same day the Niners saw George Kittle return from his Achilles injury, the team also got back McCaffrey, who had been sidelined since August 10 due to his “tightness.” Assuming he doesn’t miss any more time and we don’t hear anything else about this injury or a new one, McCaffrey appears to be in good shape to be ready in time for the Niners’ Week 1 opener when they take on the Rams in Australia 18 days from now.

There had been previous speculation, most notably from Pro Football Talk’s Mike Florio and 49ers beat guy Grant Cohn, that McCaffrey’s tightness that cropped up just days after Bijan Robinson and Jahmyr Gibbs reset the running back market was him holding in for a new contract of his own. Rapoport shot that down in a report Monday night, calling the timing of the injury a coincidence. Rapoport noted that it sounds like McCaffrey was angling for a new contract over the offseason, though those talks went nowhere. In positive news for fantasy managers, he also added that it’s his understanding the injury isn’t anything to worry about, which implies McCaffrey will be ready for the start of the regular season.

The 49ers do not have to disclose any details here, so we just have to wait until McCaffrey either tells us himself or retakes the practice field. The veteran running back has plenty of time to get right for Week 1. We are not overly concerned. He remains a high-end RB1 for the 2026 season, but we will provide an update whenever we get one.

We’ll assume the vague categorization means there’s not much to worry about. It was reported in May that the 49ers wanted to be “cautious” with McCaffrey’s summer workload as he ramps up for the season, so it’s possible there’s a little bit of load management going on here while McCaffrey works through this “tightness.” The 49ers have seen several notable players go down due to injuries early in camp. Hopefully this is a non-issue for CMC, and we see him back on the practice field soon.

McCaffrey practiced with the team on Wednesday. He was held out of team drills on Thursday and worked on his conditioning on a side field instead. Late in March, coach Kyle Shanahan said he wants less “wear and tear” on McCaffrey this season. The plan to reduce wear and tear may be limited to the practice week. McCaffrey told reporters today that he thinks “the workload in our sport is really monitored in practice, not in games,” and that he likes to prepare himself “for playing every snap.” McCaffrey posted a league-leading and career-high 413 touches last season. If sitting out practices regularly allows him to handle a similar workload this season, he will once again compete for the overall RB1 spot in fantasy.

It’s not the first time we’ve heard this, and it certainly won’t be the last, but it’s understandable that Shanny would want to dial back McCaffrey’s workload this season. The star running back is entering his age-30 season and coming off a 2025 in which he saw a career-high 311 carries while rushing for 1,202 yards and 10 scores. McCaffrey also caught 102 passes for 924 yards and another seven touchdowns, turning in one of his best seasons as a pro while eclipsing 2,000 scrimmage yards for the third time in his career. It’s possible the 49ers find a way to delegate more work to second-year back Jordan James or a player not yet on the roster, but this shouldn’t change how we view McCaffrey’s fantasy stock this season. As long as he’s healthy, CMC remains one of the most dynamic weapons in the league and should see plenty of touches funneled his way, making him one of the most valuable assets in all formats.