Tank Dell (knee) limited again in return from IR

Adams cashed in on a corner fade from four yards out in the second quarter and ran a beautiful route on a double move slant from five yards out for his second score in the fourth quarter, proving that he remains an elite red zone weapon for an offense that has now attempted 51 or more passes in three straight games. Adams is back to modest target rates following the Week 4 return of Puka Nacua but remains a weekly WR2 due to his red zone acumen, which remains true ahead of a much more forgiving matchup against the Cardinals in Week 6.

Higbee continued to operate as the primary pass-catching tight end against the Bills, something that must please fantasy managers considering Colby Parkinson returned from a one-game absence. Furthermore, the team carried only three tight ends on the active game-day roster after being at either four or five through the first month of the 2026 season. Higbee is a middling TE2 in fantasy circles ahead of a juicy matchup against the divisional rival Cardinals in Week 6.

Nacua operated as the primary option through the air for a Rams team that attempted more than 50 passes for the third straight game. The veteran alpha was mostly confined to short-area work, something that could be attributed to the groin injury that continues to have his name on the injury report in practice, but that would not keep Nacua from returning another elite WR1 performance. Nacua was also inches away from padding his stat line further after failing to come down with what would have been a 51-yard touchdown reception on the final play of the first half. Nacua and the Rams fall to 2-3 ahead of a Week 6 divisional showdown against the Cardinals, where he will remain one of the top fantasy assets in the league.

Corum provided a much needed spark in relief of lead back Kyren Williams, contributing three clutch receptions that kept drives alive in addition to a third quarter touchdown. That said, his modest volume continued while Williams turned in a third straight game with 20 or more opportunities, including 28 total targets in that stretch. Corum remains a top fantasy handcuff but is unlikely to return useful fantasy weeks for as long as Williams is healthy.

Williams has yet to see more than the 16 carries he saw against the Bills this season but the team’s recent pass-heavy nature has left the veteran lead back with six or more receptions in three straight games, including 27 total targets in that span. The elite-level aerial volume made it three consecutive games with 20 or more opportunities for Williams, who continues to return RB1 fantasy weeks while playing in one of the league’s top offenses. Williams remains a middling RB1 ahead of a Week 6 divisional showdown against the Cardinals at home.

It was the third consecutive game in which Stafford attempted 51 passes or more in what has become the most voluminous passing offense in the league. The two powerhouses felt each other out throughout the first half as only 20 combined points per scored before the break. Things would get aggressive for the final 30 minutes as seven combined touchdowns were scored on nine second half possessions, four of which were accounted for by the Rams. Stafford directed a whopping 24 targets toward alpha wide receiver Puka Nacua, who set a career high with 17 receptions in a short-area role. The reigning MVP returned an instant classic performance against the 2024 MVP, ultimately coming up short in overtime following a blocked field goal attempt from Harrison Mevis. The Rams fall to 2-3 ahead of a home matchup against the more forgiving Cardinals in Week 6. Stafford is once again a fantasy QB1 in that matchup.

The Bills clearly came into this one intent on establishing the run, attempting 37 rushes to just 19 Josh Allen pass attempts in a game played without both DJ Moore and Joshua Palmer. Kincaid has now seen three or fewer targets in each of his last three games after erupting for 225 yards through the air in the first two weeks. The ceiling was never in question, but fantasy managers have to be reeling after three consecutive down performances for the enigmatic tight end. Kincaid remains an upside TE1 ahead of a Week 6 meeting with the Raiders.

Coleman was largely erased by the lockdown corner play of the Rams but had a receiving line also heavily influenced by a ground-heavy game plan from a Bills team that attempted only 19 passes in almost 70 minutes of football. It was quite the letdown fantasy performance for managers looking to take advantage of the absences of both DJ Moore and Joshua Palmer. Coleman is a borderline FLEX play in Week 6 against the Raiders, pending the status of Moore.

Shakir’s modest target total was primarily a product of a ground-heavy approach from the Bills, who were playing without both DJ Moore and Joshua Palmer. His quiet fantasy outing was quickly remedied through a 57-yard, catch-and-run reception on the team’s second possession of overtime to set up the game-winning, Tyler Bass field goal. Shakir remains a shaky fantasy bet ahead of a Week 6 meeting with the Raiders.

Cook’s elite rushing line was overshadowed by two fumbles, the second of which was a lost fumble on the team’s first possession of overtime, placing the Rams in position to complete the comeback and steal away the victory. A blocked field goal on what would have been the game-winning kick breathed new life into the Bills, who demonstrated confidence in their lead back by throwing him right back out there on the following possession to eventually win the game. The 26 touches go down as a season high for the veteran back, who found paint for the fourth consecutive game in the thrilling overtime win. Cook remains a top-tier RB1 for fantasy purposes ahead of a Week 6 meeting with the Raiders in Las Vegas.