After two empty drives, the Seahawks got on the board with their third.
Rookie running back Kenneth Walker ran in a 7-yard touchdown to cap the possession, making the score 10-7, 49ers.
Seattle needed 14 plays to go 78 yards, taking 6:57 off the clock.
The Seahawks converted a pair of third downs, with quarterback Geno Smith hitting receiver Tyler Lockett for a 6-yard gain on third-and-4. Then the team used a direct snap to Walker to convert third-and-1 for a first-and-goal at the 7-yard line.
On the next play, Walker made his way into the end zone.
Walker now has 41 yards rushing while Smith has started the game 5-of-6 passing for 33 yards.