Two teams struggling for consistency but confirmed playoff teams and certain Super Bowl contenders meet Sunday in Orchard Park when the Philadelphia Eagles (10-5) take on the Buffalo Bills (11-4).
The defending Super Bowl champs, the Eagles have rebounded from a three-game losing streak to win their last two and, in the process, repeat as NFC East champions. Philly is the first team in the division to repeat since they did it back in 2004. It snapped the longest streak without a repeat champ by any division in NFL history.
The Bills are riding a four-game winning streak. Sunday will mark the first of two home games to close the regular season for Buffalo. It will be their final two games at Highmark Stadium. Buffalo is 6-1 at home this season with the lone loss coming in Week 5 to New England. The Bills trail the Patriots by one game in the AFC East.
Lets take a look at the matchup including a few key stats and trends, the quarterbacks, and those listed on the injury report.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates courtesy of Rotoworld, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to Watch the Eagles and the Bills live Sunday
- Date: Sunday, December 28, 2025
- Time: 4:25PM EST
- Site: Highmark Stadium
- City: Orchard Park, NY
- Network/Streaming: FOX
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Game Odds: Eagles at Bills
The latest odds as of Wednesday courtesy of DraftKings:
- Moneyline: Philadelphia Eagles (+102), Buffalo Bills (-122)
- Spread: Bills -1.5
- Total: 43.5 points
This game opened at Bills -3 with the Game Total set at 46.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup: Eagles at Bills
- Eagles Starting QB: Jalen Hurts
Last Game: 12/20 at Washington – 22-30, 185yds, 2TD, 0INTs, Sacked 2 times, 7 carries for 40yds rushing
Season: 15GP, 281-427, 3114yds, 24TDs, 6INTs, Sacked 31 times, 102 carries for 416yds rushing - Bills Expected Starting QB: Josh Allen
Last Game: 12/21 at Dallas – 23-29, 300yds, 2TDs, 0INTs, Sacked 0 times, 8 carries for 42yds rushing
Season: 15GP, 296-425, 3406yds, 25TDs, 10INTs, Sacked 35 times, 105 carries for 552yds rushing - Bills Potential Starting QB: Mitch Trubisky
Last Game: 11/9 at Miami – 0-0, 0yds, 0TDs, 0INTs, 0 Sacks, 1 carry for 4yds rushing
Season: 3GP, 3-6, 54yds, 0TDs, 0INTs, 0 Sacks, 4 carries for 1yd rushing
Eagles at Bills: Team Stats and Betting Trends
- James Cook leads the NFL with 1,532 yards rushing
- During the Bills’ current 4-game winning streak has rushed for 448 yds (5.1yds/attempt) and scored 5 total TD (4 rush)
- Saquon Barkley rushed for 132 yards on 21 carries last Sunday vs. Washington
- The Eagles are 9-6 ATS this season
- The Bills are 7-8 ATS this season
- The OVER has cashed in 6 of the Eagles’ 15 games this season (6-9)
- The OVER has cashed in 8 of the Bills’ 15 games this season (8-7)
Eagles Player Injuries
- RT Lane Johnson (foot) is listed as questionable for Sunday’s game
- DE Jalen Carter (shoulder) is listed as questionable for Sunday’s game
- LB Nakobe Dean (hamstring) is listed as questionable for Sunday’s game
- TE Cameron Latu (neck) is listed as questionable for Sunday’s game
- OT Cameron Williams (shoulder) is eligible to be activated from the IR
Bills Player Injuries
- QB Josh Allen (foot) is listed as questionable for Sunday’s game
- DT DaQuan Jones (undisclosed) is listed as questionable for Sunday’s game
- DT Jordan Phillips (ankle) is listed as questionable for Sunday’s game
- LB Shaq Thompson (neck) is listed as questionable for Sunday’s game
- S Jordan Poyer (hamstring) is listed as questionable for Sunday’s game
- PK Matt Prater (quad) is listed as questionable for Sunday’s game
Rotoworld Best Bets
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Eagles and the Bills
- Moneyline: Rotoworld Bet is leaning towards a play on the Eagles on the Moneyline.
- Spread: Rotoworld Bet is leaning towards a play on the Eagles +1.5.
- Total: Rotoworld Bet is recommending a play on the Game Total OVER 43.5.
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