Boston listed as No. 1 WR on early depth chart

Hudson tore his pec in Week 5’s win over the Dolphins. The injury will likely keep him sidelined for the remainder of the regular season. Hudson had played 28 percent of the team’s offensive snaps and seen seven targets through five games, mostly functioning as a blocker. Drew Sample would see more snaps with Hudson sidelined.

With Deebo Samuel sustaining a serious hamstring injury in Week 5 against Seattle, Cooks stepped in and functioned as San Francisco’s No. 2 receiver behind Mike Evans. Cooks was targeted on 17 percent of his pass routes against the Seahawks and caught a touchdown on his only reception. Though Jacob Cowing could mix in with Samuel sidelined, Cooks should be in line for a few targets a game. The well-traveled veteran can be picked up in deeper fantasy formats this week.

Henderson suffered his latest ankle injury in Week 5 against the Raiders. Schefter said Henderson is “regarded as a quick healer, so the Patriots are hoping his return is sooner rather than later.” Still, he could be sidelined for the next few weeks, leaving Rhamondre Stevenson as the team’s clear lead back. Corey Kiner, meanwhile, appears to be in line as the Patriots’ RB2 after seeing seven touches last week against the Raiders. Kiner should be stashed in most 12-team fantasy leagues for now. Stevenson profiles as a top-12 play until Henderson returns.

Harrison, who sustained the injury in Week 5 against the Eagles, could miss the rest of the season once doctors determine the severity of his knee injury, according to NFL Network’s Ian Rapoport. Harrison had protected Trevor Lawrence’s blindside before the injury. His absence could be a problem for a Jacksonville offensive line that has the league’s third worst pass blocking win rate.

Adams cashed in on a corner fade from four yards out in the second quarter and ran a beautiful route on a double move slant from five yards out for his second score in the fourth quarter, proving that he remains an elite red zone weapon for an offense that has now attempted 51 or more passes in three straight games. Adams is back to modest target rates following the Week 4 return of Puka Nacua but remains a weekly WR2 due to his red zone acumen, which remains true ahead of a much more forgiving matchup against the Cardinals in Week 6.

Higbee continued to operate as the primary pass-catching tight end against the Bills, something that must please fantasy managers considering Colby Parkinson returned from a one-game absence. Furthermore, the team carried only three tight ends on the active game-day roster after being at either four or five through the first month of the 2026 season. Higbee is a middling TE2 in fantasy circles ahead of a juicy matchup against the divisional rival Cardinals in Week 6.

Nacua operated as the primary option through the air for a Rams team that attempted more than 50 passes for the third straight game. The veteran alpha was mostly confined to short-area work, something that could be attributed to the groin injury that continues to have his name on the injury report in practice, but that would not keep Nacua from returning another elite WR1 performance. Nacua was also inches away from padding his stat line further after failing to come down with what would have been a 51-yard touchdown reception on the final play of the first half. Nacua and the Rams fall to 2-3 ahead of a Week 6 divisional showdown against the Cardinals, where he will remain one of the top fantasy assets in the league.

Corum provided a much needed spark in relief of lead back Kyren Williams, contributing three clutch receptions that kept drives alive in addition to a third quarter touchdown. That said, his modest volume continued while Williams turned in a third straight game with 20 or more opportunities, including 28 total targets in that stretch. Corum remains a top fantasy handcuff but is unlikely to return useful fantasy weeks for as long as Williams is healthy.

Williams has yet to see more than the 16 carries he saw against the Bills this season but the team’s recent pass-heavy nature has left the veteran lead back with six or more receptions in three straight games, including 27 total targets in that span. The elite-level aerial volume made it three consecutive games with 20 or more opportunities for Williams, who continues to return RB1 fantasy weeks while playing in one of the league’s top offenses. Williams remains a middling RB1 ahead of a Week 6 divisional showdown against the Cardinals at home.

It was the third consecutive game in which Stafford attempted 51 passes or more in what has become the most voluminous passing offense in the league. The two powerhouses felt each other out throughout the first half as only 20 combined points per scored before the break. Things would get aggressive for the final 30 minutes as seven combined touchdowns were scored on nine second half possessions, four of which were accounted for by the Rams. Stafford directed a whopping 24 targets toward alpha wide receiver Puka Nacua, who set a career high with 17 receptions in a short-area role. The reigning MVP returned an instant classic performance against the 2024 MVP, ultimately coming up short in overtime following a blocked field goal attempt from Harrison Mevis. The Rams fall to 2-3 ahead of a home matchup against the more forgiving Cardinals in Week 6. Stafford is once again a fantasy QB1 in that matchup.