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    Niners move Guerendo to reserve/PUP

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    SF Running Back #31
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    49ers placed Isaac Guerendo to the reserve/PUP list.

    Guerendo, still recovering from a pec injury, will miss at least the first four weeks of the regular season. This helps to clarify the Niners backfield situation headed into the season. Behind Christian McCaffrey will be some combination of Kaelon Black — who has drawn praise from coaches and QB Brock Purdy — and Jordan James, who missed most of training camp with a rib injury. Guerendo is a long way from playing time in the Niners offense.
PFT Draft: Best matchups of Week 8
Chris Simms and Mike Florio pick their favorite matchups of NFL Week 8, including Lamar Jackson vs. Josh Allen, Baker Mayfield vs. Kevin Stefanski and Mike Macdonald vs. Ben Johnson.

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  • SF Running Back #31
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    This is just one reporter’s opinion, but 26-year-old Guerendo’s health has taken on increased importance after Jordan James suffered a broken rib in the opening days of camp. Guerendo’s Niners future is murky at best, but a quick healing process could earn him a small role behind workhorse Christian McCaffrey, as well as make it more likely he would be a part of the committee were CMC to ever miss time with injury.
  • SF Tight End #85
    Speaking to the media Saturday, 49ers general manager John Lynch said that Kittle, Alfred Collins, and Isaac Guerendo will be moved to the PUP list ahead of the start of camp but that he is “optimistic on all of them hitting the practice field sooner than later.” As a reminder, players can be moved from the PUP list at any point during camp, meaning the fact that they currently find themselves with that designation does not mean they will miss anything meaningful to their fantasy value in 2026.
  • SF Running Back #31
    49ers head coach Kyle Shanahan broke the news this afternoon. This is a bummer. Earlier this month, The Athletic’s Vic Tafur said he believed Guerendo was “buried” on the depth chart and will likely “be looking for a new team” at some point. The team could end up releasing him with an injury settlement, but we suppose some sort of reserve list placement is possible. 49ers RBs Jordan James and Kaelon Black can be expected to compete for RB2 duties at this time. The team also signed RBs Jordan Mims and Jermar Jefferson today.
  • SF Running Back #31
    Same. After Kaelon Black was added in the third round, it seems like he’ll be the real competitor for Jordan James in the backup spot. Guerendo didn’t exactly play poorly when given a chance, but the 49ers simply have to draft a running back every year per unspoken NFL guidelines. If Guerendo is released, he could be an interesting reclamation project elsewhere.
  • SF Running Back #29
    We’d heard that they’d had “big plans” for James, but this is more concrete. 49ers HC Kyle Shanahan said Isaac Guerendo “wasn’t the team’s second best runner” last year and “fell behind James in that category by the end of the season.” It seems the 49ers believe in Guerendo more as a pass-catcher, but they only have two healthy backs up as an operating principle. James didn’t have much of a regular season, but did have six rushes for 28 yards in garbage time against the eventual champion Seahawks in the Divisional Round. He’ll have some fantasy upside this year behind an aging Christian McCaffrey.
  • SF Running Back #29
    It’s an interesting assertion because James rarely played this year, starting the season with a wrist injury and eventually playing only three offensive snaps in three active regular season games. However, James did close out the Divisional Round loss to the Seahawks with six carries for 28 yards and it appears he could seize the No. 2 role behind Christian McCaffrey if Brian Robinson walks in free agency. Isaac Guerendo, per Tafur, “seems like an easy cut” if Robinson returns.
  • SF Running Back #23
    NFL Network’s Tom Pelissero implicitly confirms the concern that McCaffrey did indeed suffer a new injury, saying the 49ers’ “opener against Seattle is on Sunday, just three days after the injury” occurred, removing the possibility that this was a precautionary measure due to some sort of muscle irritation. Pelissero previously reported that “alarm bells” are not going off within the 49ers’ facility, but the new injury-related phrasing is hardly comforting. For now, fantasy managers must prepare to be without McCaffrey, while hoping for the best. No. 2 RB Brian Robinson will be a top-18 option if McCaffrey is sidelined for Week 1. No. 3 RB Isaac Guerendo is worth adding in 12-team leagues, where available.
  • SF Running Back
    After missing several weeks with a shoulder injury and apparently falling out of favor with the Niners’ coaching staff, Isaac Guerendo will enter the season as the team’s RB3 behind Christian McCaffrey and Robinson, who was acquired on Friday in exchange for draft compensation. “We brought him here to be our (No.) 2 back,” Shanahan said of Robinson, who last year in Washington had 799 rushing yards and eight touchdowns as the Commanders’ lead back. “I’ve always been a big fan of Brian. Loved him coming out college... We were pumped that he was available and pumped that we were able to get him.” That’s as much confirmation as fantasy managers are going to need in understanding the San Francisco backfield pecking order. Robinson should be drafted in all fantasy formats in case McCaffrey misses time this season.
  • SF Running Back #31
    He missed just over two weeks with a shoulder injury. Guerendo should slot right back in as Christian McCaffrey’s main backup over Jeff Wilson going forward. It’s possible Guerendo gets a little run in the final preseason game to make sure he’s fully ready for the regular season.
  • SF Running Back
    Wilson, 29, has spent the last 2.5 seasons in Miami after being dealt to the Dolphins during the 2022 trade deadline. Since then, the veteran back has struggled with injuries and an inability to find consistent playing time in a Dolphins backfield that has been ripe with young, explosive talent. Wilson’s signing comes after the 49ers lost Isaac Guerendo (shoulder) for"a few weeks” and rookie Jordan James to a broken finger. Both running backs could have a chance to be ready for the start of the season, but they’ll be cutting it close. Wilson spent five seasons playing with the Niners in Kyle Shanahan’s system and can provide a sense of familiarity to the backfield. Wilson rushed for 57 scoreless yards on 16 carries last season and shouldn’t be viewed as a permanent fixture on the 49ers’ roster once Guerendo and James are able to return.

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    Eagles signed Jaydon Blue from the practice squad to the active roster.

    Blue was called up as the replacement for Dameon Pierce, who was placed on injured reserve this week. Saquon Barkley entered Week 7 with a lingering hamstring issue. He then suffered a back injury and was in and out of the lineup for the remainder of the game. With little left to play for, the Eagles may choose to put their star running back on ice for a while. That would leave Blue and Elijah Mitchell as the next men up. Mitchell was the RB3 for Philly in Monday’s game, but he wasn’t signed to the active roster. Our money is on Blue seeing more work this week, though it’s a messy situation at best.
  • CHI Defensive Tackle #98
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    Bears acquired DT Jeffery Simmons and a fifth-round pick from the Titans in exchange for two first-round picks and a fourth-round pick.

    The Titans’ fourth-round pick is in 2027 and the fifth-round pick heading back to Chicago is in 2028. It’s a massive haul for a Titans team that is once again staring down the barrel of a lost season. Simmons has been the subject of trade rumors for a while, but an offseason extension quieted the murmurs this year. Tennessee inked him to a three-year, $106 million extension in June. Simmons has consistently been one of the league’s best interior pass-rushers. He racked up a career-high 11 sacks last year and already has four to his name in 2026. Though the Titans clearly wanted Simmons to be around for years to come, they couldn’t pass on the chance to hoard draft picks as they prepare for another rebuild. With Caleb Williams healthy and playing at an elite level, the Bears are going all in on this current window. They currently rank 14th in EPA per play allowed, a mark that will certainly improve in the coming weeks.
  • GB Wide Receiver #0
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    NFL Network’s Ian Rapoport reports Matthew Golden (shoulder/foot) is “trending toward playing” in Week 8 against the Panthers.

    Golden was estimated as a DNP for two walkthroughs this week before being limited in the Packers’ only real session. The short turnaround to Thursday Night Football likely forced the Packers to take an extra cautious approach with him in practice. While he almost certainly isn’t at 100 percent, Golden looks like a good bet to play in a sneaky shootout with the Panthers tonight. He will be on the WR1/2 border if he gets the green light.
  • ARI Wide Receiver #14
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    Michael Wilson (ribs) was limited in Wednesday’s practice.

    Wilson was on the practice field wearing a non-contact jersey on Wednesday. He is dealing with a rib injury, presumably suffered in the Cardinals’ Week 7 loss to the Broncos. He will be limited as long as he wears the non-contact jersey and ideally finishes the week without it in order to play in Week 8 against the Cowboys. Kendrick Bourne suddenly becomes the WR1 if Wilson cannot go.
  • ARI Running Back #22
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    Tyler Allgeier (toe) did not practice Wednesday.

    Allgeier popped up on the injury report with a toe issue as rookie Jeremiyah Love (ankle) returned to practice in a limited fashion. Though we don’t know the severity of Allgeier’s injury, it may be worth keeping Bam Knight rostered despite Love’s return. If Allgeier cannot play in Week 8 against the Cowboys, Knight will get another week of fantasy viability.
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    Jihaad Campbell (hamstring/quad) did not participate in Wednesday’s walkthrough practice.

    Campbell came out of the Eagles’ Week 7 loss to the Cowboys dealing with hamstring and quad injuries. He starts out the week as an estimated DNP. Campbell will likely need to practice in some capacity in order to play Week 8 against the Commanders.
  • PHI Wide Receiver #6
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    DeVonta Smith (hamstring) did not participate in Wednesday’s walkthrough practice.

    Both Smith and Dontayvion Wicks (ankle) were estimated DNPs for the Eagles’ walkthrough. Both players missed Week 7 against the Cowboys and start off on the wrong side of questionable to open Week 8. Smith and Wicks will need to at least get a limited practice session in before they can be considered as potential fantasy options against the Commanders. With Britain Covey (knee) also DNP, the receiving corps is sparse. If neither can go, Darius Cooper and Hollywood Brown get a boost from the WR group while TE Dallas Goedert becomes the No. 1 pass-catcher in the Eagles offense.
  • PHI Running Back #26
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    Saquon Barkley (hamstring/back) did not participate in Wednesday’s walkthrough practice.

    Barkley was predictably a non-participant after re-aggravating his hamstring injury and additionally injuring his back in Week 7 against the Cowboys. Despite the injuries, ESPN’s Adam Schefter reported that Barkley said his hamstring “came out great” and he doesn’t believe his back will keep him out. With every other Eagles running back suffering long-term injuries, Barkley is attempting to gut out his injury issues. Given his re-aggravation last week, it is well within the range of outcomes for Barkley to see limited snaps in Week 8 against the Commanders. His motivation to play makes us think he is on track to be active on Sunday but Barkley is a risky RB2 as he deals with injuries.
  • WAS Defensive Tackle #99
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    Javon Kinlaw (knee) did not practice Wednesday.

    Kinlaw is dealing with a knee issue. Commanders head coach Dan Quinn said Wednesday it will “likely be tough” for the 29-year-old defensive tackle to play Sunday. We can expect Kinlaw to be on the wrong side of questionable for Week 8 against the Eagles.
  • WAS Wide Receiver #3
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    Stefon Diggs (hand/hamstring/rest) did not practice Wednesday.

    Commanders head coach Dan Quinn already said Diggs won’t practice Wednesday, so this is not a surprise. Quinn also confirmed the veteran will return to practice Thursday and the additional rest designation should stave off concerns of Diggs dealing with a long-term injury. He should be in the WR3/FLEX mix for Week 8 against the Eagles. Also not practicing for the Commanders was TE John Bates (shoulder).